Publication: Características cognitivas y neurofisiológicas en ancianos sanos con factores de riesgo genético de Enfermedad de Alzheimer
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2019-05-20
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Universidad Complutense de Madrid
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Abstract
A pesar de la gran cantidad de investigaciones que se han llevado a cabo en relación a la Enfermedad de Alzheimer (EA) en los últimos 20 años, aún no se ha desarrollado un tratamiento eficaz para detener o retrasar su progresión. En la actualidad, uno de los temas de mayor interés consiste en la búsqueda de marcadores tempranos que permitan predecir la EA, tanto para el diagnóstico precoz, como para su prevención mediante la intervención farmacológica y/o la estimulación cognitiva. En este sentido, los factores de riesgo genético cobran especial protagonismo al contribuir en más de un 60% al desarrollo de esta enfermedad.Cada vez es mayor el número de trabajos focalizados en la búsqueda de genes candidatos, estudios de asociación del genoma completo (GWAS en inglés), etc., con el fin de proporcionar nuevas perspectivas sobre su patogénesis y los beneficios que podrían derivarse de un abordaje precoz de la misma. Gracias a ello se sabe que el ser portador del alelo ε4 del gen de la apolipoproteína E (APOE ε4) es el factor de riesgo genético más importante de la EA de origen tardío. Asimismo, se han descubierto polimorfismos genéticos de diversos genes (CLU, PICALM, CR1 o BDNF) que también parecen estar asociados con la enfermedad...
Despite a great deal of research into Alzheimer’s disease (AD) over the last 20 years, an effective treatment to halt or slow its progression has yet to be developed. Nowadays, the identification of early biomarkers in order to predict AD is essential not only for early diagnosis, but also for its proper prevention through pharmachological or cognitive interventions. In this sense, genetic risk factors gain special prominence since they account for more than 60% to the development of the disease.In fact, there is a growing number of works focused on the search for candidate genes, genome-wide association studies (GWAS), etc., to help us map the genetic information in AD, which can provide a new insight into the pathogenesis of the disease as well as the benefits that could be derived from an early approach. Thanks to this type of studies, it is known that the ε4 allele of the apolipoprotein E gene (APOE ε4) is one of the most recognizable risk factors for late-onset AD susceptibility. Additionally, another genetic polymorphisms, which seem to be associated with AD, have been also discovered (e.g. CLU, PICALM, CR1 or BDNF)...
Despite a great deal of research into Alzheimer’s disease (AD) over the last 20 years, an effective treatment to halt or slow its progression has yet to be developed. Nowadays, the identification of early biomarkers in order to predict AD is essential not only for early diagnosis, but also for its proper prevention through pharmachological or cognitive interventions. In this sense, genetic risk factors gain special prominence since they account for more than 60% to the development of the disease.In fact, there is a growing number of works focused on the search for candidate genes, genome-wide association studies (GWAS), etc., to help us map the genetic information in AD, which can provide a new insight into the pathogenesis of the disease as well as the benefits that could be derived from an early approach. Thanks to this type of studies, it is known that the ε4 allele of the apolipoprotein E gene (APOE ε4) is one of the most recognizable risk factors for late-onset AD susceptibility. Additionally, another genetic polymorphisms, which seem to be associated with AD, have been also discovered (e.g. CLU, PICALM, CR1 or BDNF)...
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Tesis de la Universidad Complutense de Madrid, Facultad de Psicología, Departamento de Psicología Experimental, Procesos Cognitivos y Logopedia, leída el 30-11-2018