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TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.

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Román González, Elvira and Huertas, Blanca and Prieto, Daniel and Díez Orejas, Rosalía and Pla Alonso, Jesús (2018) TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut. Future microbiology, 13 . pp. 857-867. ISSN 1746-0921

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Official URL: https://www.futuremedicine.com/



Abstract

AIM

To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut.

MATERIALS & METHODS

We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines.

RESULTS

The colonization rates reached with the TUP1-RFP strain were lower compared with wild-type strain and completely absent after induction of filamentation. No differences in the susceptibility to bile salts nor in the adhesion to the mouse intestine epithelium were observed.

CONCLUSION

Blockage of C. albicans in a filamentous form impedes gut cell colonization in the mouse.


Item Type:Article
Uncontrolled Keywords:Candida albicans, Commensalism, Filamentous growth, TUP1
Subjects:Medical sciences > Pharmacy > Microbiology
ID Code:55649
Deposited On:22 Jul 2019 08:03
Last Modified:22 Jul 2019 14:21

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