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The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway.

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Román, Elvira and Correia, C. Inês Ribeiro and Prieto, Daniel and Alonso Monge, Rebeca and Pla Alonso, Jesús (2019) The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway. International microbiology : the official journal of the Spanish Society for Microbiology . ISSN 1618-1905

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Abstract

In 1993, Brewster and Gustin described the existence of a kinase whose activity was essential for Saccharomyces cerevisiae to grow in environments with high osmolarity. This led to the discovery of the HOG pathway, a MAP kinase (MAPK) pathway that has been revealed to be crucial to respond to a wide range of stress conditions frequently encountered by fungi in their common habitats. MAPK signaling is initiated at the plasma membrane, where triggering stimuli lead to a phosphorylation cascade that ultimately activates transcription factors to ensure an appropriate adaptive response. In pathogenic fungi, the HOG pathway gains special significance as it is involved in traits related to pathogenicity; these include biofilm formation, adhesion to surfaces, and morphogenetic and epigenetic transitions. It also plays a role in controlling both the pathogen and the commensal state program. Understanding the signals leading to its activation, the elements of the pathways and the targets of the pathway are therefore of primary importance in the design of novel antifungals.


Item Type:Article
Subjects:Medical sciences > Pharmacy > Microbiology
ID Code:55653
Deposited On:18 Jul 2019 11:28
Last Modified:19 Jul 2019 07:27

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