Publication: Regulación de la expresión génica en respuesta a inhibidores de β-1,3-glucán sintasa en "Saccharomyces cerevisiae"
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2019-06-11
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Universidad Complutense de Madrid
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Abstract
La pared celular fúngica es una envoltura rígida esencial para proteger a la célula de las condiciones ambientales adversas preservando la integridad celular. Esta estructura está constituida principalmente por polisacáridos y proteínas. Así, la pared celular se organiza en cadenas de β-1,3-glucano con ramificaciones de β- 1,6-glucano formando una matriz a la que se une covalentemente la quitina y las manoproteínas. La ausencia de esta estructura en células eucariotas superiores hace de ella una diana potencial para agentes antifúngicos. Entre los compuestos utilizados en la actualidad en la terapia antifúngica se encuentra la caspofungina, cuyo mecanismo de acción es la inhibición del complejo β-1,3-glucan sintasa (GS). De esta forma, el tratamiento con este fármaco afecta a la síntesis de β-1,3-glucano, principal componente de la pared celular fúngica, y por tanto, a la integridad de la misma...
The fungal cell wall is a rigid envelope essential to protect the cell from adverse environmental conditions while preserving cell integrity. This structure mainly consists of polysaccharides and proteíns. Thus, the cell wall is organized into β-1,3-glucan chains with β-1,6-glucan branches forming a matrix to which chitin and mannoproteíns are covalently bound. The absence of cell wall in higher eukaryotic cells makes this structure a potential target for antifungal agents. Among the compounds having antifungal activity used in the clinic, caspofungin inhibits the β-1,3-glucan synthase (GS) complex. Accordingly, treatments employing this drug affect the synthesis of β-1,3-glucan, main component of the fungal cell wall, and therefore, its integrity...
The fungal cell wall is a rigid envelope essential to protect the cell from adverse environmental conditions while preserving cell integrity. This structure mainly consists of polysaccharides and proteíns. Thus, the cell wall is organized into β-1,3-glucan chains with β-1,6-glucan branches forming a matrix to which chitin and mannoproteíns are covalently bound. The absence of cell wall in higher eukaryotic cells makes this structure a potential target for antifungal agents. Among the compounds having antifungal activity used in the clinic, caspofungin inhibits the β-1,3-glucan synthase (GS) complex. Accordingly, treatments employing this drug affect the synthesis of β-1,3-glucan, main component of the fungal cell wall, and therefore, its integrity...
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Tesis de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Microbiología y Parasitología, leída el 23-11-2018