Publication: Estrategias computacionales en el desarrollo de neurofármacos: una tecnología de éxito
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2019-06-12
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Universidad Complutense de Madrid
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Abstract
La química médica es una de las consideradas ciencias farmacéuticas, cuyo objetivo fundamental es la identificación y desarrollo de nuevos fármacos, seguros y efectivos, para el tratamiento de diversas patologías. La química médica se engloba en un ámbito multidisciplinar, que aúna química, biología y farmacia, y multitud de técnicas derivadas de éstas.El proceso de descubrimiento y desarrollo de un fármaco es un proceso largo, que dura en torno a unos 15 años, con un alto coste (cercano a los 1000 millones de euros), y con una baja tasa de éxito (1/5000). Todas las complicaciones asociadas a este proceso hacen de él un camino largo y difícil de abordar, por lo que el uso de nuevas herramientas, que faciliten este camino, ha sido una objetivo clave en la investigación básica. Una de las diferentes técnicas que han tenido un mayor crecimiento en las últimas décadas son las técnicas computacionales. El desarrollo, desde los años 1950, de las ciencias informáticas, en conjunto con la mejora de los recursos computacionales, y su aplicación a la química médica mediante las técnicas de modelado molecular, ha supuesto un punto de inflexión en el desarrollo de proyectos racionales de obtención de nuevos fármacos...
Medicinal chemistry is one of the considered pharmaceutical sciences, whose main objective is the identification and development of new drugs, safe and effective, for the treatment of several diseases. Medicinal chemistry is encompassed in a multidisciplinary field, which combines chemistry, biology and pharmacy, and a multitude of techniques derived from them.Drug discovery and development is a long process, lasting around 15 years, with a high cost (close to 1000 million euros), and with a low success rate (1/5000). All the complications associated with this process make it a long and difficult path to tackle, so the use of new tools that facilitate this path has been a key objective in basic research. One of the different techniques that have had a greater improvement in the last decades are the computational techniques. The development of computer science, since the 1950s, together with the improvement of computational resources, and its application to medicinal chemistry through molecular modeling techniques, has meant a turning point in the development of rational projects in order to obtain new drugs...
Medicinal chemistry is one of the considered pharmaceutical sciences, whose main objective is the identification and development of new drugs, safe and effective, for the treatment of several diseases. Medicinal chemistry is encompassed in a multidisciplinary field, which combines chemistry, biology and pharmacy, and a multitude of techniques derived from them.Drug discovery and development is a long process, lasting around 15 years, with a high cost (close to 1000 million euros), and with a low success rate (1/5000). All the complications associated with this process make it a long and difficult path to tackle, so the use of new tools that facilitate this path has been a key objective in basic research. One of the different techniques that have had a greater improvement in the last decades are the computational techniques. The development of computer science, since the 1950s, together with the improvement of computational resources, and its application to medicinal chemistry through molecular modeling techniques, has meant a turning point in the development of rational projects in order to obtain new drugs...
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Tesis de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Química en Ciencias Farmacéuticas, leída el 26-10-2018