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Dynamic energy budget approach to evaluate antibiotic effects on biofilms

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Birnir, Bjorn and Carpio, Ana and Cebrián, Elena and Vidal, Perfecto (2018) Dynamic energy budget approach to evaluate antibiotic effects on biofilms. Communications in Nonlinear Science and Numerical Simulation, 54 . pp. 70-83. ISSN 1007-5704

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Official URL: https://doi.org/10.1016/j.cnsns.2017.05.016




Abstract

Quantifying the action of antibiotics on biofilms is essential to devise therapies against chronic infections. Biofilms are bacterial communities attached to moist surfaces, sheltered from external aggressions by a polymeric matrix. Coupling a dynamic energy budget based description of cell metabolism to surrounding concentration fields, we are able to approximate survival curves measured for different antibiotics. We reproduce numerically stratified distributions of cell types within the biofilm and introduce ways to incorporate different resistance mechanisms. Qualitative predictions follow that are in agreement with experimental observations, such as higher survival rates of cells close to the substratum when employing antibiotics targeting active cells or enhanced polymer production when antibiotics are administered. The current computational model enables validation and hypothesis testing when developing therapies.


Item Type:Article
Uncontrolled Keywords:Dynamic energy budget, Bacterial biofilm, Antibiotic, Numerical simulation
Subjects:Sciences > Mathematics > Differential equations
Sciences > Mathematics > Operations research
Medical sciences > Medicine > Pharmacology
ID Code:55852
Deposited On:18 Jun 2019 15:27
Last Modified:19 Jun 2019 07:49

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