Publication: Diabetes y cáncer
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2017-06
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Abstract
La diabetes mellitus y el cáncer son dos enfermedades que han ido creciendo con los años y que presentan una elevada prevalencia en la actualidad. La diabetes tipo 2 parece encontrarse relacionada con determinados tipos de cáncer, al igual que parece aumentar su recurrencia y mortalidad. Estas dos patologías pueden verse conectadas por los factores de riesgo que ambas comparten, sobre todo por la obesidad, y los mecanismos biológicos, siendo los puntos claves la insulina, el IGF-1 y las vías de señalización que activan, que en situación de hiperinsulinemia, pueden llevar a cabo un papel fundamental en el desarrollo de cáncer. Entre los fármacos usados para el tratamiento de la diabetes tipo 2, se puede diferenciar entre aquellos que parecen influir en la aparición de cáncer y fármacos, como la metformina, que parece ejercer un efecto protector antitumoral al disminuir la mortalidad y la recurrencia de cáncer, por lo que su co-administración junto a quimioterapia en pacientes diabéticos con cáncer, parece mejorar la clínica de esta situación.
Diabetes mellitus and cancer are two diseases that have been growing over the years and have a high prevalence nowadays. Type 2 diabetes seems to be related with certain cancers and it seems to increase the recurrence and the mortality of these cancers. These two pathologies may be connected to each other by risk factors they both share, above all, obesity and biological mechanisms, with key points being insulin and IGF-1 and signaling pathways they activate, which in a situation of hyperinsulinemia, they can be relevant in the development of cancer. Among the drugs used for the treatment of type 2 diabetes, one can differentiate between those that appear to influence the onset of cancer and drugs, like metformina, which appears to exert an antitumor protective effect. This is because it decreases cancer mortality and recurrence, so its co-administration with chemotherapy in diabetic patients with cancer seems to improve the clinical situation.
Diabetes mellitus and cancer are two diseases that have been growing over the years and have a high prevalence nowadays. Type 2 diabetes seems to be related with certain cancers and it seems to increase the recurrence and the mortality of these cancers. These two pathologies may be connected to each other by risk factors they both share, above all, obesity and biological mechanisms, with key points being insulin and IGF-1 and signaling pathways they activate, which in a situation of hyperinsulinemia, they can be relevant in the development of cancer. Among the drugs used for the treatment of type 2 diabetes, one can differentiate between those that appear to influence the onset of cancer and drugs, like metformina, which appears to exert an antitumor protective effect. This is because it decreases cancer mortality and recurrence, so its co-administration with chemotherapy in diabetic patients with cancer seems to improve the clinical situation.