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Concanavalin A-targeted mesoporous silica nanoparticles for infection treatment.

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Martínez Carmona, Marina and Izquierdo Barba, Isabel and Colilla, Montserrat and Vallet Regí, María (2019) Concanavalin A-targeted mesoporous silica nanoparticles for infection treatment. Acta Biomaterialia . ISSN 1742-7061 (In Press)

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Abstract

The ability of bacteria to form biofilms hinders any conventional treatment for chronic infections and has serious socio-economic implications. For this purpose, a nanocarrier capable of overcoming the barrier of the mucopolysaccharide matrix of the biofilm and releasing its loadedantibiotic within this matrix would be desirable. Herein, we developed a new nanosystem based on
levofloxacin (LEVO)-loaded mesoporous silica nanoparticles (MSNs) decorated with the lectin concanavalin A (ConA). The presence of ConA promotes the internalization of this nanosystem into the biofilm matrix, which increases the antimicrobial efficacy of the antibiotic hosted within the mesopores. This nanodevice is envisioned as a promising alternative to conventional
treatments for infection by improving the antimicrobial efficacy and reducing side effects.


Item Type:Article
Additional Information:

RESEARCHER ID N-3992-2014 (Marina Martínez Carmona)
ORCID 0000-0002-2026-6266 (Marina Martínez Carmona)
RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba)
ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba)
RESEARCHER ID N-4628-2014 (Montse Colilla Nieto)
ORCID 0000-0003-1961-4160 (Montse Colilla Nieto)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Biofilm,Bacterial infection, Lectin, Mesoporous Silica Nanoparticles, Nanomedicine, Synergistic Combination, Targeting
Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:56193
Deposited On:22 Jul 2019 09:06
Last Modified:22 Jul 2019 14:19

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