Publication: Implicación del IGF-1 en el envejecimiento cardiovascular
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2017-06
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Abstract
El IGF-1 es un péptido pequeño similar a la insulina que se sintetiza a partir de la GH en muchos órganos y por tanto sus efectos son múltiples, entre ellos destacan el efecto cardioprotector y vasoprotector. Con la edad los niveles de GH disminuyen por cambios en el sistema endocrino lo que produce una disminución en la síntesis de IGF-1 y como consecuencia una alteración en el sistema cardiovascular impidiendo que tengan lugar los efectos citados anteriormente. Los bajos niveles de IGF-1 se asocian con un mayor riesgo de enfermedades cardiovasculares por la disfunción cardiovascular que produce, así como con un envejecimiento cardiovascular acelerado. Según varios estudios la sobreexpresión de IGF-1 puede tener efectos beneficiosos en las células cardiacas progenitoras mejorando o incluso impidiendo el riesgo de insuficiencia cardiaca. Por otro lado la disminución de los niveles circulantes de IGF-1 se asocian con la rarefacción microvascular ya que los efectos antiapoptóticos, proangiogénicos y neurotróficos de dicho factor no se llevan a cabo. Además una deficiencia de IGF-1 está relacionada con un aumento en la producción de ROS y una disminución de la biodisponibilidad de NO promoviendo el envejecimiento vascular.
The IGF-1 is a small peptide similar to insulin which is synthesized from GH in many organs and therefore its effects are mutliple. Among them are the cardioprotective and vasoprotective effects. With age, the levels of GH decrease due to changes in the endocrine system, which leads to a decrease in the synthesis of IGF-1 and in consequence to a change in the cardiovascular system, preventing ocurrence of the effects mentioned previously. The low levels of IGF-1 are linked to a higher risk of cardiovascular sicknesses, due to the cardiovascular dysfunction it provokes, as well as to an accelerated cardiovascular aging. According to numerous studies, the over expression of IGF-1 can have beneficial effects in progenitor cardiac cells improving or even avoiding the risk of cardiac failure. On the other hand, the decrease in the circulating levels of IGF-1 are linked to the microvascular rarefaction due to the fact that the antiapoptotic, proangiogenic and neurotrophic effects of such factor are not carried out. Also, a deficiency of IGF-1 is related with an increase of ROS production and a decrase in the bioavailability of NO promoting vascular aging.
The IGF-1 is a small peptide similar to insulin which is synthesized from GH in many organs and therefore its effects are mutliple. Among them are the cardioprotective and vasoprotective effects. With age, the levels of GH decrease due to changes in the endocrine system, which leads to a decrease in the synthesis of IGF-1 and in consequence to a change in the cardiovascular system, preventing ocurrence of the effects mentioned previously. The low levels of IGF-1 are linked to a higher risk of cardiovascular sicknesses, due to the cardiovascular dysfunction it provokes, as well as to an accelerated cardiovascular aging. According to numerous studies, the over expression of IGF-1 can have beneficial effects in progenitor cardiac cells improving or even avoiding the risk of cardiac failure. On the other hand, the decrease in the circulating levels of IGF-1 are linked to the microvascular rarefaction due to the fact that the antiapoptotic, proangiogenic and neurotrophic effects of such factor are not carried out. Also, a deficiency of IGF-1 is related with an increase of ROS production and a decrase in the bioavailability of NO promoting vascular aging.