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Soluble defense collagens: sweeping up immune threats

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Casals Carro, Cristina and García-Fojeda, Belén and Minutti, Carlos M. (2019) Soluble defense collagens: sweeping up immune threats. Molecular Immunology, 112 . pp. 291-304. ISSN 0161-5890, ESSN: 1872-9142

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Official URL: https://www.sciencedirect.com/science/article/pii/S0161589019302937



Abstract

Soluble defense collagens form a group of secreted proteins that are primarily involved in host defense. All defense collagens contain a globular recognition domain contiguous to a collagen-like triple helical domain. They are oligomeric proteins, assembled in multiples of three subunits due to their collagen domains. Members of this group include collectins such as surfactant protein A and D (SP-A, SP-D), and mannan-binding lectin; C1q, the first component of the complement system; adiponectin; and ficolins. All are secreted to tissue cavities or serum. Soluble defense collagens are specialized to respond to infection, triggering the initiation of the complement cascade and/or enhancing phagocytosis of pathogens by macrophages. However, once inflammation is established, C1q, collectins, ficolins, or adiponectin can influence macrophage responses, thereby contributing to resolve the inflammation. In addition, some members of this group of proteins (SP-A, C1q, and adiponectin) modulate tissue-repair functions of macrophages. This review will focus on the molecular mechanisms by which these proteins efficiently defend against immune threats and contribute to tissue repair.


Item Type:Article
Uncontrolled Keywords:Collectins; Ficolins; C1q; Adiponectin; Efferocytosis; Tissue repair
Subjects:Medical sciences > Biology > Biochemistry
ID Code:56588
Deposited On:07 Oct 2019 08:01
Last Modified:07 Oct 2019 10:27

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