Publication: Fotosensibilización de oxígeno singlete: aplicaciones al estudio de la fotooxidación de tiocetonas y fotoerradicación de H. pylori
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2019-07-30
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Universidad Complutense de Madrid
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Abstract
La investigación que se ha llevado a cabo en este trabajo (Fotosensibilización de oxígeno singlete: aplicaciones al estudio de la fotooxidación de tiocetonas y fotoerradicación de H. pylori) centra su interés en el aprovechamiento de la energía transportada por la luz y su transferencia mediante fotosensibilización a la molécula de oxígeno para generar su estado excitado de menor energía, el oxígeno molecular singlete (1O2). La producción de esta especie reactiva del oxígeno puede ser aplicada en campos tan diversos como la síntesis química en el contexto de la Química Verde (Green Chemistry), en métodos de descontaminación medioambiental como los procesos avanzados de oxidación(Advanced Oxidation Processes), o en nuevos tratamientos médicos como las terapias fotodinámicas (Photodynamic Therapies) contra microorganismos resistentes a antibióticos o contra algunos tipos de cáncer. En definitiva, este estudio persigue avanzar en el conocimiento sobre la aplicación alternativa de la luz, un recurso potencialmente inagotable, para conseguir algunos de los objetivos fundamentales que se plantea la sociedad para un futuro cercano: el desarrollo de una industria química sostenible, la conservación del medioambiente, así como nuevos caminos para mejorar la salud y vivir mejor...
The research presented in this work (Photosensitization of singlet oxygen: applications to the study of photooxidation of thioketones and photoeradication of H. pylori) is focused on the current interest on taking advantage of the energy transported by light and its transfer by photosensitization to the oxygen molecule to generate its excited state of lowest energy, singlet molecular oxygen (1O2). The production of this reactive oxygen species can be applied in fields as diverse as chemical synthesis in the context of Green Chemistry, in environmental decontamination methods such as Advanced Oxidation Processes, or in new medical treatments such as Photodynamic Therapies against antibiotic-resistant microorganisms or against some types of cancer. In short, this study aims to advance knowledge about the alternative application of light, a potentially inexhaustible resource, in order to achieve some of the fundamental objectives that society sets for the near future: the development of a sustainable chemical industry, the conservation of the environment, as well as new ways to improve health and live better...
The research presented in this work (Photosensitization of singlet oxygen: applications to the study of photooxidation of thioketones and photoeradication of H. pylori) is focused on the current interest on taking advantage of the energy transported by light and its transfer by photosensitization to the oxygen molecule to generate its excited state of lowest energy, singlet molecular oxygen (1O2). The production of this reactive oxygen species can be applied in fields as diverse as chemical synthesis in the context of Green Chemistry, in environmental decontamination methods such as Advanced Oxidation Processes, or in new medical treatments such as Photodynamic Therapies against antibiotic-resistant microorganisms or against some types of cancer. In short, this study aims to advance knowledge about the alternative application of light, a potentially inexhaustible resource, in order to achieve some of the fundamental objectives that society sets for the near future: the development of a sustainable chemical industry, the conservation of the environment, as well as new ways to improve health and live better...
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Tesis de la Universidad Complutense de Madrid, Facultad de Ciencias Químicas, Departamento de Química Orgánica I, leída el 01/03/2019