Publication: Papel del eje MDK/ALK en células iniciadoras del glioma: implicaciones terapéuticas
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2019-08-06
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Universidad Complutense de Madrid
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Abstract
El glioblastoma multiforme (GBM) es una de las formas más agresivas de cáncer. Estos tumores se caracterizan por presentar una alta resistencia a los tratamientos quimio y radioterapéuticos utilizados actualmente. Se ha propuesto que este hecho podría deberse, al menos en parte, a la presencia dentro de estos tumores de una subpoblación minoritaria de células denominadas células iniciadoras de glioma o GICs (utilizando su acrónimo en inglés Glioma Initiating Cells) y que podrían ser responsables de las recidivas características de estos tumores. De esta manera, la determinación de los factores de crecimiento y las vías de señalización implicadas en la auto‐renovación y las propiedades tumorigénicas es esencial para diseñar nuevas estrategias dirigidas de una forma más específica frente a esta población celular. Estudios previos han demostrado que el factor neurotrófico MIDQUINA (MDK) se asocia con un mal pronóstico en pacientes con GBM, con lo que en la presente Tesis Doctoral nos preguntamos si la MDK podría participar en la regulación de la biología de las GICs...
Glioblastoma multiforme (GBM) is one of the most aggressive forms of cancer. It has been proposed that the presence within these tumors of a population of cells with stem‐like features termed Glioma stem‐like cells or Glioma Initiating Cells (GICs) exhibiting a high resistance to chemo and radiotherapy is responsible for the relapses that almost invariably take place in the patients with this disease. Therefore, the identification of the growth factors and signalling pathways involved in the regulation of the self‐renewal and tumorigenic properties of these cells is essential to design new therapeutic strategies aimed at targeting more specifically this cell population. Previous studies showed that increased levels of the neurotrophic factor MIDKINE (MDK) are associated with poor prognosis in patients with GBM. In this work, we investigated the role of MDK in the regulation of GICs biology...
Glioblastoma multiforme (GBM) is one of the most aggressive forms of cancer. It has been proposed that the presence within these tumors of a population of cells with stem‐like features termed Glioma stem‐like cells or Glioma Initiating Cells (GICs) exhibiting a high resistance to chemo and radiotherapy is responsible for the relapses that almost invariably take place in the patients with this disease. Therefore, the identification of the growth factors and signalling pathways involved in the regulation of the self‐renewal and tumorigenic properties of these cells is essential to design new therapeutic strategies aimed at targeting more specifically this cell population. Previous studies showed that increased levels of the neurotrophic factor MIDKINE (MDK) are associated with poor prognosis in patients with GBM. In this work, we investigated the role of MDK in the regulation of GICs biology...
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Tesis de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, Departamento de Bioquímica y Biología Molecular, leída el 15-03-2019