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Structural and Functional Diversity of Microbial Metallothionein Genes

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Gutiérrez Fernández, Juan Carlos and Francisco Martínez, Patricia de and Amaro Torres, Francisco and Díaz, Silvia and Martín González, Ana María (2018) Structural and Functional Diversity of Microbial Metallothionein Genes. In Microbial Diversity in the Genomic Era. Elsevier, pp. 387-407. ISBN 978-0-12-814849-5

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Official URL: https://www.sciencedirect.com/science/article/pii/B9780128148495000228



Abstract

In the present review, we discussed the concept of metallothionein (MT) and analyzed the structural and functional diversity of microbial MTs, grouping them into three main groups; bacteria, fungi, and protists. Structural diversity is analyzed based on the primary, secondary, and/or tertiary structure of the proteins. Their ability to bind different metals is also analyzed in each microbial group. An in silico and phylogenetic analysis of MT sequences from the main microbial groups has been carried out. The wide functional diversity of these proteins and the regulation of the MT gene expression are also discussed. The presence of several paralog genes in many microorganisms provides a coordinated and multiple response against different types of environmental stressors. Likewise, the main possible biotechnological applications of these proteins are explored, such as molecular tools to design biosensors for evaluating metal contamination and in metal bioremediation.


Item Type:Book Section
Uncontrolled Keywords:Microbial metallothioneins, paralog genes, structural diversity, gene regulation, biotechnological applications
Subjects:Medical sciences > Biology > Genetics
Medical sciences > Biology > Microbiology
ID Code:56791
Deposited On:22 Aug 2019 16:44
Last Modified:22 Aug 2019 16:44

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