Publication: Valor pronóstico de marcadores inflamatorios en pacientes con fractura pertrocantérea de cadera
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2019-08-23
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Universidad Complutense de Madrid
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Abstract
La fractura de cadera continúa siendo la causa más frecuente de ingreso en los Servicios de Cirugía Ortopédica y Traumatología en España. Aunque su incidencia ha disminuido levemente en los últimos años, se considera un evento que afecta negativamente por un lado a la esperanza de vida de las personas que la sufren y por otro a la morbilidad de las personas mayores, por su impacto sobre la marcha y sobre su nivel de dependencia. La medición de diversas citoquinas como reflejo del estado inflamatorio del paciente está cobrando interés al haberse demostrado su utilidad, por ejemplo en pacientes politraumatizados, sépticos, o incluso tras infarto de miocardio. Se ha empezado a emplear de manera habitual el término fragilidad para definir el estado fisiológico de los pacientes con dificultades para afrontar un evento estresante que afecte a su homeostasis. En los últimos años está cobrando interés la relación entre la fragilidad de los pacientes y su situación inflamatoria, habiéndose descrito el impacto negativo que sobre la morbi-mortalidad tiene el hecho de constatarse un estado proinflamatorio o ser catalogado como persona frágil...
Hip fractures are the most frequent pathology for admission in an Orthopedics Department in Spain. Although its incidence has decreased slightly in recent years, it is still considered an event that negatively affects life expectancy of the people who suffer it and increase morbidity of the elderly, due to its impact on walking and on dependency. Measurement of cytokines to investigate the inflammatory status of the patient is gaining interest since its usefulness has already been demonstrated, for example in trauma patients, septic patients, or even after myocardial infarction. The term frailty is becoming commonly used to define the physiological condition of patients with difficulties in coping with a stressful event that affects their homeostasis. In recent years, the relationship between frailty patients and their inflammatory situation is rising interest, as it has been described the negative impact on morbidity and mortality of having a pro-inflammatory status or being classified as frailty person...
Hip fractures are the most frequent pathology for admission in an Orthopedics Department in Spain. Although its incidence has decreased slightly in recent years, it is still considered an event that negatively affects life expectancy of the people who suffer it and increase morbidity of the elderly, due to its impact on walking and on dependency. Measurement of cytokines to investigate the inflammatory status of the patient is gaining interest since its usefulness has already been demonstrated, for example in trauma patients, septic patients, or even after myocardial infarction. The term frailty is becoming commonly used to define the physiological condition of patients with difficulties in coping with a stressful event that affects their homeostasis. In recent years, the relationship between frailty patients and their inflammatory situation is rising interest, as it has been described the negative impact on morbidity and mortality of having a pro-inflammatory status or being classified as frailty person...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Cirugía, leída el 29-05-2019