Publication: Determinación de las mutaciones en los codones 12 y 13 del gen K-RAS, polimorfismo Arg72Pro del gen TP53 y análisis de la inestabilidad de microsatélites en tumores vesicales no músculo invasivos de riesgo intermedio y alto
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2019-08-26
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Universidad Complutense de Madrid
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Abstract
Los TVNMI son un grupo heterogéneo de tumores cuya capacidad de recidivar o progresar es variable. Las mutaciones en los codones 12 y 13 del gen KRAS (oncogen), polimorfismo Arg72Pro del gen TP53 (gen supresor de tumores) y/o la inestabilidad de los microsatélites BAT 25, BAT 26 y D2S123 han sido involucrados en la génesis tumoral de una u otra manera del cáncer vesical. Estos biomarcadores podrían suponer una herramienta que identificase el pronóstico al diagnóstico, con las ventajas que ello puede aportar en su seguimiento. OBJETIVOS:1. Analizar la presencia de mutaciones puntuales de los codones 12 y 13 del gen KRAS, el polimorfismo Arg72Pro del gen TP53 y la inestabilidad de los microsatélites (MSI) BAT 25, BAT 26 y D2S123 en una serie de pacientes diagnosticados de TVNMI (tumor vesical no músculo-invasivo) con riesgo intermedio o alto para la recidiva y progresión.2. Estudiar su valor pronóstico para la recidiva y progresión...
Non-muscle invasive bladder cancer (NMIBC) are a heterogeneous group of tumors with different recurrence and progression rates. Mutations in codons 12 and 13 of the KRAS gene (oncogene), Arg72Pro polymorphism of the TP53 gene (tumor suppressor gene) and / or the instability of the microsatellite BAT 25, BAT 26 and D2S123 have been involved in bladder cancer genesis. These biomarkers could be a tool to predict long-term risks of desease recurrence and progression in individual patients. OBJECTIVES: 1. To analyze the presence of mutations in codons 12 and 13 of the KRAS gene, the Arg72Pro polymorphism of the TP53 gene and the instability of microsatellites (MSI) BAT 25, BAT 26 and D2S123 in a series of patients diagnosed of NMIBT with intermediate or high risk for recurrence and progression. 2. Study its prognostic value for recurrence and progression. MATERIAL..
Non-muscle invasive bladder cancer (NMIBC) are a heterogeneous group of tumors with different recurrence and progression rates. Mutations in codons 12 and 13 of the KRAS gene (oncogene), Arg72Pro polymorphism of the TP53 gene (tumor suppressor gene) and / or the instability of the microsatellite BAT 25, BAT 26 and D2S123 have been involved in bladder cancer genesis. These biomarkers could be a tool to predict long-term risks of desease recurrence and progression in individual patients. OBJECTIVES: 1. To analyze the presence of mutations in codons 12 and 13 of the KRAS gene, the Arg72Pro polymorphism of the TP53 gene and the instability of microsatellites (MSI) BAT 25, BAT 26 and D2S123 in a series of patients diagnosed of NMIBT with intermediate or high risk for recurrence and progression. 2. Study its prognostic value for recurrence and progression. MATERIAL..
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Cirugía, leída el 28-06-2019