Publication: Estudio del papel del epitelio pulmonar en la alergia: el polen de olivo como modelo experimental
Loading...
Files
Official URL
Full text at PDC
Publication Date
2019-09-09
Authors
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Complutense de Madrid
Citations
Exportar
Abstract
La alergia respiratoria es uno de los problemas de salud pública con mayor impacto social a nivel mundial, cuya prevalencia ha aumentado de forma alarmante durante los últimos años. Su etiología es compleja e implica la interacción de factores genéticos, factores ambientales y el estilo de vida de los países desarrollados. Este desorden clínico se caracteriza por un proceso inflamatorio de las vías respiratorias, dominado poruna respuesta inmune en la que participan linfocitos tipo T-colaboradores 2 (Th2) y la presencia de elevados niveles de inmunoglobulina E específica en el suero frente a sustancias ambientales, denominadas aeroalérgenos, que normalmente son inocuas para la mayoría de los individuos. Cada vez hay más evidencias del importante papel del epitelio respiratorio como integrador y regulador de la respuesta alérgica..
Respiratory allergy is one of the public health problems with greatest social impact worldwide, whose prevalence has alarmingly increased in recent years. Allergy etiology is complex and involves the interaction of genetic, environmental factors and the influence of developed countries lifestyle. This clinical disorder is characterized by an exacerbated inflammatory process of the respiratory tract, dominated by an immune response T-helper type 2 (Th2) and the presence in the serum of high levels of specific immunoglobulin E against environmental substances, called aeroallergens, usually harmless to most individuals. In this sense, there is an increasing evidence of the crucial role of the respiratory epithelium as a main regulator of the allergic responses.
Respiratory allergy is one of the public health problems with greatest social impact worldwide, whose prevalence has alarmingly increased in recent years. Allergy etiology is complex and involves the interaction of genetic, environmental factors and the influence of developed countries lifestyle. This clinical disorder is characterized by an exacerbated inflammatory process of the respiratory tract, dominated by an immune response T-helper type 2 (Th2) and the presence in the serum of high levels of specific immunoglobulin E against environmental substances, called aeroallergens, usually harmless to most individuals. In this sense, there is an increasing evidence of the crucial role of the respiratory epithelium as a main regulator of the allergic responses.
Description
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Químicas, Departamento de Bioquímica y Biología Molecular, leída el 29-04-2019