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Neuroprotective and Anti-Inflammatory Effects of a Hydrophilic Saffron Extract in a Model of Glaucoma

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Fernández Albarral, José Antonio and Ramírez Sebastián, Ana Isabel and Hoz Montañana, Rosa de and López Villarín, Nerea and García Martín, Elena Salobrar and López Cuenca, Inés and Licastro, Ester and Inarejos García, Antonio M. and Almodóvar, Paula and Pinazo Durán, Mª Dolores and Ramirez Sebastian, Jose Manuel and Salazar Corral, Juan José (2019) Neuroprotective and Anti-Inflammatory Effects of a Hydrophilic Saffron Extract in a Model of Glaucoma. International Journal of Molecular Sciences, 20 (17). p. 4110. ISSN 1422-0067

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Official URL: https://doi.org/10.3390/ijms20174110




Abstract

Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs). An increase in the intraocular pressure is the principal risk factor for such loss, but controlling this pressure does not always prevent glaucomatous damage. Activation of immune cells resident in the retina (microglia) may contribute to RGC death. Thus, a substance with anti-inflammatory activity may protect against RGC degeneration. This study investigated the neuroprotective and anti-inflammatory effects of a hydrophilic saffron extract standardized to 3% crocin content in a mouse model of unilateral, laser-induced ocular hypertension (OHT). Treatment with saffron extract decreased microglion numbers and morphological signs of their activation, including soma size and process retraction, both in OHT and in contralateral eyes. Saffron extract treatment also partially reversed OHT-induced down-regulation of P2RY12. In addition, the extract prevented retinal ganglion cell death in OHT eyes. Oral administration of saffron extract was able to decrease the neuroinflammation associated with increased intraocular pressure, preventing retinal ganglion cell death. Our findings indicate that saffron extract may exert a protective effect in glaucomatous pathology.


Item Type:Article
Additional Information:

Received: 18 July 2019 / Revised: 19 August 2019 / Accepted: 20 August 2019 / Published: 22 August 2019

Uncontrolled Keywords:Ganglion cells; Microglia; Retina; Experimental glaucoma; Saffron extract; Brn3a; Iba-1; P2RY12; Neuroprotection; Neuroinflammation
Subjects:Medical sciences > Medicine > Neurosciences
Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
ID Code:57093
Deposited On:25 Sep 2019 12:25
Last Modified:30 Sep 2019 11:48

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