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Safety data on in situ gelling bimatoprost loaded nanovesicular formulations

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Yadav, Monika and Guzmán Aránguez, Ana Isabel and Pérez de Lara, María Jesús and Singh, Mandeep and Singh, Joga and Pal Kaur, Indu (2019) Safety data on in situ gelling bimatoprost loaded nanovesicular formulations. Data in Brief, 25 . ISSN 2352-3409

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Official URL: https://doi.org/10.1016/j.dib.2019.104361




Abstract

In vitro cytotoxicity and in vivo acute and 7 days repeat-dose ocular toxicity studies, were conducted in rabbits, in accordance with the Organisation for Economic Co-operation and Development (OECD) guidelines, for bimatoprost loaded nanovesicular aqueous dispersion (BMT-NV) and its in-situ gelling sub-conjunctival implant (BMT-NV-IM). For details on the preparation and evaluation of BMT-NV and its BMT-NV-IM for the control of glaucoma, please refer to ‘Bimatoprost loaded nanovesicular long-acting sub-conjunctival in-situ gelling implant: In vitro and in vivo evaluation’ (Yadav et al., 2019). The in vivo ocular toxicity was performed only after confirming dermal safety, as required by OECD. Histological evaluation of various ocular tissues, following sub-conjunctival implantation with BMT-NV-IM, was done for ocular tolerance studies.


Item Type:Article
Additional Information:

Received 10 May 2019, Revised 19 July 2019, Accepted 29 July 2019, Available online 6 August 2019.
Refers to: Bimatoprost loaded nanovesicular long-acting sub-conjunctival in-situ gelling implant: In vitro and in vivo evaluation

Uncontrolled Keywords:Cytotoxicity; Ocular toxicity; In situ gelling; Acyte and repeat dose toxicity; Sub-conjunctival implants; Cell lines
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Pharmacy > Drugs
ID Code:57110
Deposited On:04 Oct 2019 12:28
Last Modified:04 Oct 2019 12:28

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