Universidad Complutense de Madrid
E-Prints Complutense

Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge

Impacto

Downloads

Downloads per month over past year

Acaz Fonseca, Estefanía and Ortiz Rodriguez, Ana and Azcoitia Elías, Iñigo and García-Segura, Luis Miguel and Arévalo, María Ángeles (2019) Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge. Cell Death Discovery, 5 (85). ISSN 2058-7716

[img]
Preview
PDF
Creative Commons Attribution.

2MB

Official URL: https://www.nature.com/articles/s41420-019-0166-6#rightslink



Abstract

In the nervous system, Notch pathway has a prominent role in the control of neuronal morphology and in the determination of the astrocyte fate. However, the role of Notch in morphological astrocyte plasticity is unknown. Here, we have explored the role of Notch activity on the morphological reactivity of primary astrocytes in response to LPS, an inflammatory stimulus. We found that LPS induces reactive astrocyte morphology by the inhibition of Notch signaling via NFκB activation and Jagged upregulation. In contrast, IGF-1, an anti-inflammatory molecule, inhibits LPS-induced reactive astrocyte morphological phenotype by enhancing Notch signaling through the inhibition of NFκB and the activation of MAPK. Therefore, Notch signaling pathway emerges as a mediator of the regulation of astrocyte morphology by inflammatory and anti-inflammatory stimuli.


Item Type:Article
Subjects:Medical sciences > Biology > Cytology
ID Code:57284
Deposited On:08 Oct 2019 15:35
Last Modified:09 Oct 2019 07:36

Origin of downloads

Repository Staff Only: item control page