Publication: Papel del estradiol y la progesterona en la infección por "Chlamydia abortus" en modelos murinos y ovinos: influencia sobre la eficacia de la vacunación
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2019-11-27
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Universidad Complutense de Madrid
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Abstract
La bacteria intracelular obligada Chlamydia abortus (C. abortus), es una el agente causal del aborto enzoótico ovino (AEO). La sintomatología de esta enfermedad no se observa hasta que la bacteria coloniza la placenta, causando finalmente el aborto. Los animales infectados se convierten en portadores que diseminarán la bacteria en los siguientes estros. Este proceso de latencia/multiplicación activa, sugiere que las hormonas sexuales de la hembra, estradiol y progesterona podrían desempeñar un papel importante en la fisiopatología del AEO, afectando a la resolución de la infección clamidial y también a la eficacia de la vacunación. Sin embargo, los mecanismos a través los cuales las hormonas sexuales de la hembra afectan a la infección por C. abortus no se han estudiado en profundidad. Así pues, el objetivo principal de esta tesis doctoral, ha sido analizar el efecto de las hormonas sexuales, 17β-estradiol y progesterona, sobre la cinética de la infección y la respuesta inmunitaria inducida por C. abortus en modelos experimentales murinos y ovinos.
The obligate intracellular bacterium Chlamydia abortus (C. abortus) is a causative agent of enzootic ovine abortion (OEA). The symptomatology of this disease is not observed until the bacteria colonizes the placenta, eventually causing the abortion. Infected animals become carriers that will spread the bacteria in the following estruses. This process of latency active/multiplication suggests that the female sex hormones, estradiol and progesterone hormones might play an important role in the physiopathology of OEA, affecting the success of chlamydial clearance and also jeopardising the effectiveness of vaccination. However, the mechanisms through which sex hormones are involved in chlamydial pathogenicity remai nunclear. The aim of the present doctoral thesis, therefore, was to determine the effect of sex hormones, 17β-estradiol and progesterone, on the kinetics of C. abortus-induced infection and immune response in murine and ovine experimental models...
The obligate intracellular bacterium Chlamydia abortus (C. abortus) is a causative agent of enzootic ovine abortion (OEA). The symptomatology of this disease is not observed until the bacteria colonizes the placenta, eventually causing the abortion. Infected animals become carriers that will spread the bacteria in the following estruses. This process of latency active/multiplication suggests that the female sex hormones, estradiol and progesterone hormones might play an important role in the physiopathology of OEA, affecting the success of chlamydial clearance and also jeopardising the effectiveness of vaccination. However, the mechanisms through which sex hormones are involved in chlamydial pathogenicity remai nunclear. The aim of the present doctoral thesis, therefore, was to determine the effect of sex hormones, 17β-estradiol and progesterone, on the kinetics of C. abortus-induced infection and immune response in murine and ovine experimental models...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Veterinaria, Departamento de Sanidad Animal, leída el 16-10-2019