Publication: Papel de las N-aciletanolaminas y el sistema circadiano en la homeostasis energética en peces teleósteos
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2019-11-28
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Universidad Complutense de Madrid
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Abstract
La ingestión de alimentos es un proceso multifactorial en el que intervienen una gran cantidad de elementos tanto ambientales como fisiológicos, cuya regulación se encuentra muy conservada a lo largo de la evolución, desde peces teleósteos hasta mamíferos. Así, en todos los vertebrados, tanto el sistema nervioso central como una gran cantidad de órganos periféricos funcionan de forma coordinada para establecer una óptima regulación de la ingesta. Actualmente se conocen un gran número de señales neuroendocrinas implicadas en la regulación de la homeostasis energética en los peces, como neuropéptidos, hormonas y monoaminas. Sin embargo, se ha prestado poca atención a moléculas de otra naturaleza, como los derivados lipídicos N-aciletanolaminas (NAEs), las cuáles además se han propuesto como candidatas a actuar como nexo entre el metabolismo y el sistema circadiano en los mamíferos, a través de su receptor PPARα. Por todo ello, el objetivo general de la presente Tesis Doctoral es el estudio del papel de las NAEs en la homeostasis energética de los peces e investigar la relación entre el sistema circadiano y dicha homeostasis energética, utilizando como modelo el ciprínido Carassiusauratus...
Food intake is a multifactorial process driven by a great number of environmental and physiological factors; whose regulation is highly conserved throughout the evolution from teleosts fish to mammals. Thus, in all vertebrates, both central nervous system and a wide variety of peripheral organs work in a coordinated manner to establish optimal regulation of feeding. A large number of neuroendocrine signals are currently involved in the regulation of energy homeostasis in fish, such as neuropeptides, hormones, and monoamines. However, little is known about molecules of a different nature, such as the lipid derivatives Nacylethanolamines (NAEs), which have also been suggested to be candidates to act as a link between the metabolism and the circadian system in mammals, via their receptor PPARα. Therefore, the general objective of this Doctoral Thesis is the study of the role of NAEs in the energy homeostasis of fish and to investigate the relationship between the circadian system and this energy homeostasis, using the cyprinid Carassius auratus as a model...
Food intake is a multifactorial process driven by a great number of environmental and physiological factors; whose regulation is highly conserved throughout the evolution from teleosts fish to mammals. Thus, in all vertebrates, both central nervous system and a wide variety of peripheral organs work in a coordinated manner to establish optimal regulation of feeding. A large number of neuroendocrine signals are currently involved in the regulation of energy homeostasis in fish, such as neuropeptides, hormones, and monoamines. However, little is known about molecules of a different nature, such as the lipid derivatives Nacylethanolamines (NAEs), which have also been suggested to be candidates to act as a link between the metabolism and the circadian system in mammals, via their receptor PPARα. Therefore, the general objective of this Doctoral Thesis is the study of the role of NAEs in the energy homeostasis of fish and to investigate the relationship between the circadian system and this energy homeostasis, using the cyprinid Carassius auratus as a model...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, leída el 11-10-2019