Publication: Caracterización de poblaciones celulares del linaje monocito-macrófago en órganos linfoides porcinos y su permisividad a la infección por el virus del síndrome respiratorio y reproductivo porcino (PRRSv)
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2019-11-28
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Universidad Complutense de Madrid
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Abstract
Esta tesis doctoral versa sobre la “Caracterización de poblaciones celulares del linaje monocito-macrófago en órganos linfoides porcinos y su permisividad a la infección por el Virus del Síndrome Respiratorio y Reproductivo Porcino (PRRSv).” Esta enfermedad presenta una gran prevalencia en la industria porcina a nivel mundial, en la que causa grandes pérdidas económicas. El agente etiológico, PRRSv, es un virus RNA perteneciente al género Betaarte virus y familia Arteriviridae, que por su variabilidad genética se subdivide en dos especies: PRRSv-1 y PRRSv-2. Infecta macrófagos del pulmón y de órganos linfoides, y también replica in vitro en células dendríticas derivadas de médula ósea (BMDC) o de monocitos (MoDC). CD163 y CD169 han sido descritos como los dos receptores más relevantes para la entrada y replicación del virus...
The title of this doctoral thesis is “Characterization of monocyte-macrophage lineage cell populations in porcine lymphoid organs and their susceptibility to Porcine Reproductive and Respiratory Syndrome Virus (PRRSv) infection.” This disease has a high prevalence in the swine industry worldwide, causing large economic losses. The etiologic agent is an RNA virus, PRRSv, that belongs to the genus Betaarte virus in the Arteriviridae family and based on their genetic differences is divided into two species: PRRSv-1 and PRRSv-2. The virus infects macrophages located in lung and lymphoid organs and it can also replicate in vitro in bone marrow-derived dendritic cells (BMDC) and monocyte-derived dendritic cells (MoDC). CD163 and CD169 have been described as the two most important receptors involved in PRRSv entry and replication...
The title of this doctoral thesis is “Characterization of monocyte-macrophage lineage cell populations in porcine lymphoid organs and their susceptibility to Porcine Reproductive and Respiratory Syndrome Virus (PRRSv) infection.” This disease has a high prevalence in the swine industry worldwide, causing large economic losses. The etiologic agent is an RNA virus, PRRSv, that belongs to the genus Betaarte virus in the Arteriviridae family and based on their genetic differences is divided into two species: PRRSv-1 and PRRSv-2. The virus infects macrophages located in lung and lymphoid organs and it can also replicate in vitro in bone marrow-derived dendritic cells (BMDC) and monocyte-derived dendritic cells (MoDC). CD163 and CD169 have been described as the two most important receptors involved in PRRSv entry and replication...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, Departamento de Bioquímica y Biología Molecular, leída el 13-11-2019