Universidad Complutense de Madrid
E-Prints Complutense

Changes in Retinal OCT and Their Correlations with Neurological Disability in Early ALS Patients, a Follow-Up Study

Impacto

Downloads

Downloads per month over past year

Rojas Lozano, Pilar and Hoz Montañana, María Rosa de and Ramírez Sebastián, Ana Isabel and Ferreras, Antonio and García Martín, Elena Salobrar and Muñóz Blanco, José L and Urcelay Segura, José Luis and Salazar Corral, Juan José and Ramirez Sebastian, Jose Manuel (2019) Changes in Retinal OCT and Their Correlations with Neurological Disability in Early ALS Patients, a Follow-Up Study. Brain Sciences, 9 (12). nº 337. ISSN 2076-3425

[img]
Preview
PDF
Creative Commons Attribution.

2MB

Official URL: https://doi.org/10.3390/brainsci9120337




Abstract

Background: To compare early visual changes in amyotrophic lateral sclerosis (ALS) patients with healthy controls in a baseline exploration, to follow-up the patients after 6 months, and to correlate these visual changes with neurological disability. Methods: All patients underwent a comprehensive neurological and ophthalmological examination. A linear mixed analysis and Bonferroni p-value correction were performed, testing four comparisons as follows: Control baseline vs. control follow-up, control baseline vs. ALS baseline, control follow-up vs. ALS follow-up, and ALS baseline vs. ALS follow-up. Results: The mean time from the diagnosis was 10.80 ± 5.5 months. The analysis of the optical coherence tomography (OCT) showed: (1) In ALS baseline vs. control baseline, a macular significantly increased thickness of the inner macular ring temporal and inferior areas; (2) in ALS follow-up vs. ALS baseline, a significant macular thinning in the inner and outer macular ring inferior areas; (3) in ALS follow-up vs. ALS baseline, a significant peripapillary retinal nerve fiber layer (pRNFL) thinning in the superior and inferior quadrants; and (4) ALS patients showed a moderate correlation between some OCT pRNFL parameters and Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) score. Conclusion: The OCT showed retinal changes in patients with motoneuron disease and could serve as a complementary tool for studying ALS.


Item Type:Article
Additional Information:

Received: 14 October 2019 / Revised: 12 November 2019 / Accepted: 21 November 2019 / Published: 24 November 2019

Uncontrolled Keywords:ALS; Amyotrophic lateral sclerosis; Eje; OCT; OPtic nerve; Retina
Subjects:Medical sciences > Medicine > Neurosciences
Medical sciences > Optics > Eyes anatomy
Medical sciences > Optics > Imaging systems
ID Code:58011
Deposited On:11 Dec 2019 11:51
Last Modified:11 Dec 2019 11:51

Origin of downloads

Repository Staff Only: item control page