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The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis

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Wijnker, Erik and Harashima, Hirofumi and Müller, Katja and Parra Núñez, Pablo and Bastiaan de Snoo, C. and Van de Belt, José and Dissmeyer, Nico and Bayer, Martin and Pradillo, Mónica and Schnittger, Arp (2019) The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis. Proceedings of the National Academy of Sciences, 116 (25). pp. 12534-12539. ISSN 0027-8424, ESSN: 1091-6490

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Abstract

Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis. Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assurance, a mechanism by which each chromosome receives at least one CO, resulting in all chromosomes exhibiting similar genetic lengths in weak loss-of-function cdka;1 mutants. Conversely, an increase of CDKA;1 activity resulted in elevated recombination frequencies. Thus, modulation of CDKA;1 kinase activity affects the number and placement of COs along the chromosome axis in a dose-dependent manner.


Item Type:Article
Uncontrolled Keywords:Meiosis; Cyclin-dependent kinase; Cross-over interference; Class I crossovers; Meiotic recombination
Subjects:Medical sciences > Biology > Botany
Medical sciences > Biology > Genetics
ID Code:58122
Deposited On:16 Dec 2019 12:19
Last Modified:16 Dec 2019 16:01

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