Publication: Utilidad del selenio plasmático como biomarcador en enfermedad renal crónica avanzada
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2019-12-18
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Universidad Complutense de Madrid
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Abstract
El selenio es un elemento traza esencial para mamíferos, otros animales y muchas bacterias, formando parte de numerosas enzimas o seleno proteínas. Éstas tienen funciones antioxidantes, regulatorias de la función tiroidea o del sistema inmune. El selenio está presente en el sitio activo de estas enzimas en la forma de selenocisteína. El consumo de selenio en la dieta varía ampliamente entre distintas zonas geográficas debido a la distinta disponibilidad de este elemento en los suelos. La absorción del selenio de la dieta no está regulada y tiene una alta biodisponibilidad (>50%). La toxicidad por selenio es rara y ocurre cuando hay una toma excesiva en la dieta, ya sea de forma natural en zonas geográficas con exceso de selenio en los suelos o por la ingesta de suplementos con altas dosis. Puede ocurrir una deficiencia de este elemento como consecuencia de una enfermedad, una terapia o una ingesta deficiente y crónica. Los riñones tienen un papel importante en la homeostasis del selenio y acumulan la mayor cantidad de este elemento. La isoforma plasmática de la glutatión peroxidasa se sintetiza principalmente en las células tubulares proximales renales...
Selenium is an essential trace element for mammals, other animals and many bacteria, forming part of numerous enzymes or selenoproteins. These have antioxidant activity, thyroid regulatory functions and roles on the immune system. Selenium is present in the active site of these enzymes in the form of selenocysteine. The consumption of selenium in the diet varies widely between differentg eographical locations due to the different availability of this element in soils. The absorption of selenium from the diet is not regulated and has a high bioavailability (>50%). Selenium toxicity is rare and occurs when there is excessive intake in the diet, either naturally in seleniferous areas or by the intake of supplements with high doses. Deficiency of this element can occur as a consequence of some diseases, some therapies or a chronic deficient intake. The kidneys play an important role in selenium homeostasis and they accumulate the largest amount of this element. Glutathione peroxidase plasma isoform is synthesized mainly in renal tubular proximal cells...
Selenium is an essential trace element for mammals, other animals and many bacteria, forming part of numerous enzymes or selenoproteins. These have antioxidant activity, thyroid regulatory functions and roles on the immune system. Selenium is present in the active site of these enzymes in the form of selenocysteine. The consumption of selenium in the diet varies widely between differentg eographical locations due to the different availability of this element in soils. The absorption of selenium from the diet is not regulated and has a high bioavailability (>50%). Selenium toxicity is rare and occurs when there is excessive intake in the diet, either naturally in seleniferous areas or by the intake of supplements with high doses. Deficiency of this element can occur as a consequence of some diseases, some therapies or a chronic deficient intake. The kidneys play an important role in selenium homeostasis and they accumulate the largest amount of this element. Glutathione peroxidase plasma isoform is synthesized mainly in renal tubular proximal cells...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, leída el 17/10/2019