Publication: Desarrollo galénico de formulaciones de acción antiparasitaria de extractos de Artemisia
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2019-12-19
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Universidad Complutense de Madrid
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Abstract
Las nematodosis intestinales se encuentran entre las parasitosis más prevalentes, que afectan especialmente a la población infantil. Las últimas investigaciones indican que se están desarrollando resistencias frente a los antihelmínticos comúnmente utilizados, dando lugar a niveles de eficacia inferiores a los esperados. Los extractos naturales a base de plantas con propiedades antihelmínticas constituyen una alternativa sostenible y respetuosa con el medio ambiente para el control de estas nematodosis. En los últimos años, algunas poblaciones de Artemisia absinthium han sido cultivadas experimentalmente por el Instituto de Ciencias Agrarias (ICA), obteniendo extractos carentes de los compuestos tóxicos tujonas y con una prometedora actividad nematocida. Sin embargo, las características fisicoquímicas y farmacotécnicas del extracto requieren del desarrollo de formulaciones galénicas que mejoren la biodisponibilidad y el acceso de los componentes nematocidas a las estructuras internas del nematodo para llevar a cabo su mecanismo de acción...
Intestinal nematodoses are among the most prevalent parasitosis, which especially affect the child population. The latest research indicates that resistance is developing against commonly used anthelmintics, leading to lower levels of efficacy than expected. Plant-based extracts with anthelmintic properties constitute a sustainable and environmentally friendly alternative for the control of these nematodoses. In recent years, some populations of Artemisia absinthium have been experimentally cultivated by the Institute of Agricultural Sciences (ICA), obtaining extracts -lacking the toxic compounds called thujones- with a promising nematocidal activity. However, the physicochemical and pharmacotherapeutic characteristics of the extracts require the development of galenic formulations that improve the bioavailability and access of the nematocidal components of the extract to the internal structures of the nematode, in order to carry out their mechanism of action...
Intestinal nematodoses are among the most prevalent parasitosis, which especially affect the child population. The latest research indicates that resistance is developing against commonly used anthelmintics, leading to lower levels of efficacy than expected. Plant-based extracts with anthelmintic properties constitute a sustainable and environmentally friendly alternative for the control of these nematodoses. In recent years, some populations of Artemisia absinthium have been experimentally cultivated by the Institute of Agricultural Sciences (ICA), obtaining extracts -lacking the toxic compounds called thujones- with a promising nematocidal activity. However, the physicochemical and pharmacotherapeutic characteristics of the extracts require the development of galenic formulations that improve the bioavailability and access of the nematocidal components of the extract to the internal structures of the nematode, in order to carry out their mechanism of action...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Farmacia Galénica y Tecnología Alimentaria, leída el 06/11/2019