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Effect of nutritional supplement based on melatonin on the intraocular pressure in normotensive subjects

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Carracedo Rodríguez, Juan Gonzalo and Martínez Águila, Alejandro and Rodríguez Pomar, Candela and Bodas Romero, Julia and Sánchez Naves, Juan and Pintor, Jesús (2019) Effect of nutritional supplement based on melatonin on the intraocular pressure in normotensive subjects. International Ophthalmology . pp. 1-4. ISSN 0165-5701

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Official URL: https://doi.org/10.1007/s10792-019-01199-1




Abstract

Purpose: To evaluate the effect of a new nutritional supplement based on melatonin on the intraocular pressure (IOP) in normotensive subjects.
Patients and methods: A short-term prospective study was designed. Sixty-seven normotensive subjects were recruited. Patients were divided into two groups. The daily group (DG) (n = 18) was instructed to take the supplement between 22:00 and 23:00 (before sleeping) for 3 consecutive days. IOP was measured from 10.00 to 11.00 am the day before treatment and during the 3 days of experiment. The acute group (AG) (n = 49) was instructed to take the supplement after the second measure (11.00) of the second day. IOP was measured 1 h and just before the intake of the supplement and 1 and 2 h after. All measurements in this group were taken 1 day before without any supplement (control) and the day of experiment.
Results: The DG group showed a significant decrease in IOP after supplement intake in all days of experiment, from 14.9 ± 3.4 mm Hg to 13.8 ± 2.9 mm Hg after 3 days of experiment (p value < 0.001). For AG, IOP did not change during the control day; however, a reduction of 1 mm Hg was found 2 and 3 h after supplement intake, from 15.7 ± 2.5 mm Hg to 14.7 ± 2.5 mm Hg and 15.1 ± 2.7 mm Hg, respectively, being statistically significant (p value < 0.001).
Conclusion: The supplement based on melatonin was able to reduce the IOP in normotensive subjects after 2 h of intake. Moreover, the daily intake showed a reduction in IOP during the 3 days of experiment.


Item Type:Article
Additional Information:

Received: 19 May 2019; Accepted: 19 October 2019; First Online: 24 October 2019
The final publication is available at Springer via: https://doi.org/10.1007/s10792-019-01199-1

Uncontrolled Keywords:Melatonin; Suppplements; Intraocular pressure; Coadjuvant treatments
Subjects:Medical sciences > Medicine > Biochemistry
Medical sciences > Medicine > Ophtalmology
Medical sciences > Nursing > Nutrition
Medical sciences > Optics > Eyes anatomy
ID Code:58571
Deposited On:22 Jan 2020 10:55
Last Modified:02 Mar 2020 09:02

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