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Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases

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Fernández Albarral, José Antonio and Hoz Montañana, María Rosa de and Ramírez Sebastián, Ana Isabel and López Cuenca, Inés and García Martín, Elena Salobrar and Pinazo Durán, Mª Dolores and Ramirez Sebastian, Jose Manuel and Salazar Corral, Juan José (2020) Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases. Neural Regeneration Research, 15 (8). pp. 1408-1416. ISSN 1673-5374

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Official URL: http://dx.doi.org/10.4103/1673-5374.274325




Abstract

Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressant, anxiolytic, hypolipidemic, anti-atherogenic, anti-hypertensive, antidiabetic, and anti-cancer properties. In addition, saffron has remarkable beneficial properties, such as anti-apoptotic, anti-inflammatory and antioxidant activities, due to its main metabolites, among which crocin and crocetin stand out. Furthermore, increasing evidence underwrites the possible neuroprotective role of the main bioactive saffron constituents in neurodegenerative diseases, such as Parkinson’s and Alzheimer’s diseases, both in experimental models and in clinical studies in patients. Currently, saffron supplementation is being tested for ocular neurodegenerative pathologies, such as diabetic retinopathy, retinitis pigmentosa, age-related macular degeneration and glaucoma, among others, and shows beneficial effects. The present article provides a comprehensive and up to date report of the investigations on the beneficial effects of saffron extracts on the main neurodegenerative ocular pathologies and other ocular diseases. This review showed that saffron extracts could be considered promising therapeutic agents to help in the treatment of ocular neurodegenerative diseases.


Item Type:Article
Additional Information:

Date of Submission 07-Oct-2019
Date of Decision 21-Oct-2019
Date of Acceptance 11-Nov-2019
Date of Web Publication 28-Jan-2020

Uncontrolled Keywords:AMD; Crocetin; Crocin; Crocus sativus L.; Diabetic retinopathy; Glaucoma; Neuroprotection; Ocular diseases; Retinitis pigmentosa; Saffron; Safranal
Subjects:Medical sciences > Medicine > Neurosciences
Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
ID Code:58735
Deposited On:02 Mar 2020 09:26
Last Modified:02 Mar 2020 09:47

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