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Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer’s Dementia

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García Martín, Elena Salobrar and Hoz Montañana, María Rosa de and Ramírez Sebastián, Ana Isabel and Salazar Corral, Juan José and Rojas Lozano, Pilar and López Cuenca, Inés and Fernández Albarral, José Antonio and Ramirez Sebastian, Jose Manuel (2019) Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer’s Dementia. In Alzheimer’s Disease. Codon Publications, Brisbane, pp. 159-177. ISBN 978-0-646-80968-7

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Official URL: http://dx.doi.org/10.15586/alzheimersdisease.2019.ch10




Abstract

The retina is part of the central nervous system (CNS), and therefore, in Alzheimer’s disease (AD), retinal and optic nerve degeneration could take place. This degeneration leads to neurofunctional changes that can be detected early and followed up throughout the evolution of the disease. As opposed to other CNS structures, the eye is easily accessible for in vivo observation. Retinal organization allows for the identification of its different neurons, and in consequence, detection of minimal changes taking place during neurodegeneration is possible. Functional vision studies performed on AD patients in recent years have shown how visual acuity, contrast sensitivity, color vision, and visual integration vary with the progression of neurodegeneration. The development of optical coherence tomography in ophthalmology has meant a breakthrough in retinal exploratory techniques, allowing the obtention of high-resolution images using light. This technique enables retinal analysis in the earliest stages of AD, being considered as a biomarker of neuronal damage. Given AD’s high prevalence and its expected increase, it is important to perform easy tests that cause minimal discomfort to the patients at a low cost while offering abundant information on the stage of the disease.


Item Type:Book Section
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Published: November 21, 2019

Uncontrolled Keywords:Alzheimer’s disease; Biomarker; Neurodegeneration; Retina; Visual system
Subjects:Medical sciences > Medicine > Neurosciences
Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Optometry
Medical sciences > Optics > Imaging systems
ID Code:58895
Deposited On:24 Feb 2020 15:59
Last Modified:24 Feb 2020 15:59

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