Publication: Demencia vascular: búsqueda de dianas terapéuticas en un modelo preclínico
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2020-02-18
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Universidad Complutense de Madrid
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Abstract
El término deterioro cognitivo vascular (DCV) se emplea para englobar diferentes trastornos cuyo origen es exclusivamente vascular, cubriendo un amplio espectro que abarca desde el deterioro cognitivo leve hasta un estado de demencia severa. Los primeros síntomas del deterioro cognitivo leve suelen aparecer como un enlentecimiento de las funciones cognitivas, que a menudo suelen pasar desapercibidos, progresando hacia una demencia en la que la persona necesita asistencia constante para realizar las tareas cotidianas. Este nivel de discapacidad y dependencia que la demencia genera en el paciente acarrea un impacto a nivel familiar, con unos elevados costes médicos, lo que hace que sea considerada una prioridad de salud pública, imponiéndose por ello la necesidad de hallar estrategias capaces de frenar el desarrollo y el progreso del DCV...
The concept of vascular cognitive impairment (VCI) was introduced in order to include under the same term different pathologies associated to vascular disease, ranging from mild cognitive impairment to dementia. Early signs of cognitive impairment normally consist of slower cognitive functions, which frequently goes unnoticed, and progresses to a state of dementia where the person needs constant assistance for daily tasks, such as eating, dressing or walking. The level of dependence and disability that dementia causes in a patient comes with an important family impact and also high medical costs, which makes dementia a public health priority with an urgent need to find different strategies in order to stop or slow the development of VCI...
The concept of vascular cognitive impairment (VCI) was introduced in order to include under the same term different pathologies associated to vascular disease, ranging from mild cognitive impairment to dementia. Early signs of cognitive impairment normally consist of slower cognitive functions, which frequently goes unnoticed, and progresses to a state of dementia where the person needs constant assistance for daily tasks, such as eating, dressing or walking. The level of dependence and disability that dementia causes in a patient comes with an important family impact and also high medical costs, which makes dementia a public health priority with an urgent need to find different strategies in order to stop or slow the development of VCI...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Farmacología y Toxicología, leída el 25-11-2019