Publication: Determinación del papel oncogénico de la expresión de proteínas de fusión de la vía tirosinquinasa en las neoplasias Spitzoides
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2020-02-21
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Universidad Complutense de Madrid
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Abstract
Los tumores de Spitz son neoplasias melanocíticas frecuentes en personas jóvenes. Dada la gran diversidad genética de dichos tumores se han descrito subgrupos en base a sus alteraciones genéticas únicas, que en algunos casos pueden constituir dianas terapéuticas.Objetivos Determinar la prevalencia y validar la expresión de alteraciones genéticas en las neoplasias melanocíticas de Spitz, usando técnicas de inmunohistoquímica, FISH y PCR; así como identificar las características histológicas de dichas alteraciones moleculares y comparar los resultados con nevus y melanomas convencionales. Por último proponer un algoritmo que permita predecir alteraciones moleculares en base a las características clínicas e histológicas...
Spitz tumors are melanocytic neoplasms frequently observed in young people. Studies indicate Spitz tumors are genetically diverse. Differents subgroups of Spitz tumors have been described based on their different genetic alterations, considered therapeutic targets. Objectives Determine the prevalence and expression of genetic alterations in Spitz melanocytic neoplasms, using immunohistochemical technique, FISH and PCR; as well as identifying the histological characteristics in each molecular alteration to compare the results with nevi and melanomas and finally create an algorithm that predict molecular alterations based on histological characteristics...
Spitz tumors are melanocytic neoplasms frequently observed in young people. Studies indicate Spitz tumors are genetically diverse. Differents subgroups of Spitz tumors have been described based on their different genetic alterations, considered therapeutic targets. Objectives Determine the prevalence and expression of genetic alterations in Spitz melanocytic neoplasms, using immunohistochemical technique, FISH and PCR; as well as identifying the histological characteristics in each molecular alteration to compare the results with nevi and melanomas and finally create an algorithm that predict molecular alterations based on histological characteristics...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Anatomía Patológica, leída el 29-11-2019