Publication:
Natural product-related multitarget-directed ligands for the potential treatment of neurodegenerative diseases

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2020-03-26
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Universidad Complutense de Madrid
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Neurodegenerative diseases are characterized by the loss of neurons in the brain and/or spinal cord and constitute one of the most important health problems worldwide. Although these diseases have different etiologies and clinical manifestations, they share many mechanistic pathways, including: protein misfolding, neuroinflammation, impaired mitochondrial function, increase in oxidative stress, mitochondrial disfunction, alterations in calcium homeostasis, etc...
Las enfermedades neurodegenerativas se caracterizan por la pérdida de neuronas en el cerebro y/o en la medula espinal y constituyen uno de los más importantes problemas de salud a nivel mundial. A pesar de que estas enfermedades tienen diferentes etiologías y manifestaciones clínicas, comparten diversos mecanismos, incluyendo: incorrecto plegamiento de proteínas, neuroinflamación, función mitocondrial dañada, aumento en el estrés oxidativo, disfunción mitocondrial, alteraciones en la homeostasis del calcio, etc...
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