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Natural product-related multitarget-directed ligands for the potential treatment of neurodegenerative diseases
Ligandos multidiana relacionados con productos naturales para el tratamiento potencial de enfermedades neurodegenerativas

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Cores Esperón, Ángel (2020) Natural product-related multitarget-directed ligands for the potential treatment of neurodegenerative diseases. [Thesis]

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Abstract

Neurodegenerative diseases are characterized by the loss of neurons in the brain and/or spinal cord and constitute one of the most important health problems worldwide. Although these diseases have different etiologies and clinical manifestations, they share many mechanistic pathways, including: protein misfolding, neuroinflammation, impaired mitochondrial function, increase in oxidative stress, mitochondrial disfunction, alterations in calcium homeostasis, etc...

Resumen (otros idiomas)

Las enfermedades neurodegenerativas se caracterizan por la pérdida de neuronas en el cerebro y/o en la medula espinal y constituyen uno de los más importantes problemas de salud a nivel mundial. A pesar de que estas enfermedades tienen diferentes etiologías y manifestaciones clínicas, comparten diversos mecanismos, incluyendo: incorrecto plegamiento de proteínas, neuroinflamación, función mitocondrial dañada, aumento en el estrés oxidativo, disfunción mitocondrial, alteraciones en la homeostasis del calcio, etc...

Item Type:Thesis
Directors:
DirectorsDirector email
Menéndez Ramos, José Carlos
Villacampa Sanz, Mercedes
Uncontrolled Keywords:Neurodegenerative diseases, health, treatment, molecular architecture, compounds, chemistries, drugs
Palabras clave (otros idiomas):Enfermedades neurodegenerativas, salud, tratamiento, arquitectura molecular, compuestos, quimiotecas, fármacos
Subjects:Medical sciences > Medicine > Pharmacology
Medical sciences > Medicine > Neurosciences
Medical sciences > Pharmacy > Pharmacology
Medical sciences > Pharmacy > Pharmacopoeias
Medical sciences > Pharmacy > Pharmaceutical chemistry
Medical sciences > Pharmacy > Public health
Medical sciences > Pharmacy > Pharmaceutical technology
ID Code:59744
Deposited On:26 Mar 2020 13:02
Last Modified:27 Mar 2020 07:55

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