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Normative Database of Peripapillary Vessel Density Measured by Optical Coherence Tomography Angiography and Correlation Study



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Fernández Vigo, José Ignacio and Kudsieh, Bachar and Shi, Hang and Pablo Gómez de Liaño, Lucía de and Serrano García, Irene and Ruiz Moreno, José María and Martínez de la Casa, José María and García Feijoo, Julián and Fernández Vigo, José Ángel (2020) Normative Database of Peripapillary Vessel Density Measured by Optical Coherence Tomography Angiography and Correlation Study. Current Eye Research . 8 p.. ISSN 0271-3683

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Official URL: https://doi.org/10.1080/02713683.2020.1744164


Purpose: To provide a normative data set of swept-source optical coherence tomography angiography (SS-OCTA) peripapillary vessel density (VD) measurements and assess correlations with age, gender, disc area and axial length (AL).
Material and Methods: This was an observational cross-sectional study conducted on 346 right eyes of healthy subjects. Peripapillary SS-OCTA VD measurements were obtained in the retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) in all four quadrants using the Triton device (Topcon, Nagoya, Japan). AL measurements were made by optical biometry.
Results: Mean participant age was 37.7 ± 19.8 years (range 5– 83), AL was 23.9 ± 1.3 mm (21–27), and 59% were women. Mean VDs for all quadrants were 57.2 ± 5.7% for SCP (52.4 ± 4.0% – 62.1 ± 4.2%), 46.3 ± 6.5% for DCP (41.9 ± 5.8% – 49.7 ± 4.8%) and 60.8 ± 7.4% for CC (53.4 ± 5.8% – 65.7 ± 5.5%). Negative correlation was detected between SCP VD and age (R = −0.264; P < .001), while correlation between DCP densities and age was positive (R = 0.202; P = .002). No associations were detected between peripapillary VD and gender (P ≥ 0.087) and negative correlation was found with AL and disc area only in the CC (P ≤ 0.004). In a subgroup analysis of 33 individuals, we noted no differences in VD between fellow eyes (P ≥ 0.139).
Conclusion: Peripapillary VD showed wide individual variation when measured with the Triton SS-OCTA in the different retinal plexuses and CC. While correlations were observed with age, no relationships emerged with gender and only CC showed negative correlation with AL and disc area.

Item Type:Article
Additional Information:

Received 11 Nov 2019, Accepted 10 Mar 2020, Accepted author version posted online: 18 Mar 2020, Published online: 27 Mar 2020

Uncontrolled Keywords:Peripapillary vessel density, Optic nerve head, Optical coherence tomography angiography, Glaucoma, Retinal vascular plexus
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
Medical sciences > Optics > Imaging systems
ID Code:59984
Deposited On:19 Apr 2020 16:02
Last Modified:20 Apr 2020 07:28

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