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Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules.

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Castillo, Rafael R. and Lozano Borregón, Daniel and Vallet Regí, María (2020) Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules. Pharmaceutics, 12 (5). p. 432. ISSN 1999-4923

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Official URL: https://www.mdpi.com/1999-4923/12/5/432




Abstract

The enormous versatility of mesoporous silica nanoparticles permits the creation of a large number of nanotherapeutic systems for the treatment of cancer and many other pathologies. In addition to the controlled release of small drugs, these materials allow a broad number of molecules of a very dièerent nature and sizes. In this review, we focus on biogenic species with therapeutic abilities (proteins, peptides, nucleic acids, and glycans), as well as how nanotechnology, in particular silica-based materials, can help in establishing new and more efficient routes for their administration. Indeed, since the applicability of those combinations of mesoporous silica with bio(macro)molecules goes beyond cancer treatment, we address a classification based on the type of therapeutic action.
Likewise, as illustrative content, we highlight the most typical issues and problems found in the preparation of those hybrid nanotherapeutic materials.


Item Type:Article
Additional Information:

RESEARCHER ID L-2854-2014 (Rafael Castillo Romero)
ORCID 0000-0003-1957-3098 (Rafael Castillo Romero)
RESEARCHER ID B-5081-2017 (Daniel Lozano Borregón)
ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Uncontrolled Keywords:Mesoporous silica, Therapeutic biomolecules, Proteins, Peptides, Nucleic acids, Glycans
Subjects:Sciences > Chemistry > Materials
Medical sciences > Pharmacy > Inorganic chemistry
ID Code:60443
Deposited On:02 Jun 2020 08:59
Last Modified:05 Aug 2020 10:36

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