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Aromatase: a neuroprotective enzyme

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García-Segura, Luis Miguel and Veiga, Sergio and Sierra, Amanda and Melcangi, Roberto C. and Azcoitia Elías, Iñigo (2003) Aromatase: a neuroprotective enzyme. Progress in Neurobiology, 71 (1). pp. 31-41. ISSN 1873-5118

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Official URL: https://www.sciencedirect.com/science/article/pii/S0301008203001552



Abstract

Estradiol, in addition to its participation in neuroendocrine regulation and sexual behavior, has neuroprotective properties. Different types of brain injury induce the expression of the enzyme aromatase in reactive astroglia. This enzyme catalyzes the conversion of testosterone and other C19 steroids to estradiol. Genetic or pharmacological inhibition of brain aromatase results in marked neurodegeneration after different forms of mild neurodegenerative stimuli that do not compromise neuronal survival under control conditions. Furthermore, aromatase mediates neuroprotective effects of precursors of estradiol such as pregnenolone, dehydroepiandrosterone (DHEA) and testosterone. These findings strongly suggest that local formation of estradiol in the brain is neuroprotective and that the induction of aromatase and the consecutive increase in the local production of estradiol are part of the program triggered by the neural tissue to cope with neurodegenerative insults. Aromatase may thus represent an important pharmacological target for therapies conducted to prevent aging-associated neurodegenerative disorders.


Item Type:Article
Subjects:Medical sciences > Medicine > Endocrinology
Medical sciences > Biology > Cytology
ID Code:60793
Deposited On:05 Jun 2020 12:13
Last Modified:05 Jun 2020 12:13

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