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Immune Function, Oxidative, and Inflammatory Markers in Centenarians as Potential Predictors of Survival and Indicators of Recovery After Hospital Admission

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Martínez de Toda Cabeza, Irene and Vida, Carmen and García-Salmones, Marta and Alonso-Fernández, Patricia and Fuente del Rey, Mónica de la (2019) Immune Function, Oxidative, and Inflammatory Markers in Centenarians as Potential Predictors of Survival and Indicators of Recovery After Hospital Admission. The Journals of Gerontology: Series A, 250 . ISSN 1758-535X

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Official URL: https://academic.oup.com/biomedgerontology/advance-article-abstract/doi/10.1093/gerona/glz250/5599819?redirectedFrom=fulltext



Abstract

Several parameters of immune function, oxidative, and inflammatory stresses have been proposed as markers of health and predictors of longevity and mortality. However, it is unknown if any of these parameters can be used as predictors of survival in centenarians. Therefore, in a group of 27 centenarians, at the time of admission to the Clinical Hospital of Madrid, a series of immune function, antioxidant, oxidant, and inflammatory parameters were studied. Some centenarians survived and others did not, thus establishing two groups, “survivors” (n = 9) and “nonsurvivors” (n = 18). The results show that surviving centenarians display higher neutrophil chemotaxis and microbicidal capacity, natural killer activity, lymphoproliferation, glutathione reductase activity, and basal interleukin-10 release. Moreover, lower neutrophil and lymphocyte adherence, superoxide anion and malondialdehyde concentrations, and basal release of tumor necrosis factor α are also reported. The odds ratios for survival for these parameters were also calculated, with the highest odds ratios being the lymphoproliferative capacity and the ex vivo basal and stimulated release of interleukin-6 from mononuclear cells (odds ratio = 136.00). Therefore, these parameters have the potential to be used in the clinical setting as predictors of survival in centenarians. In the survivors group, the same parameters were also analyzed after 3 months. Because survivors showed an increase in neutrophil and lymphocyte chemotaxis capacity during the recovery period, reaching similar values to those observed in healthy centenarians, these parameters could be proposed as indicators of recovery.

Resumen (otros idiomas)

En este trabajo se ha comprobado que algunos parámetros de función inmunitaria, estado redox e inflamatorio, valorados en sangre periférica de personas centenarias, en el momento de su ingreso en el hospital, pueden ser indicativos de su posterior supervivencia. Se propone la aplicación clínica de esos marcadores para evaluar el riesgo de mortalidad en esta población. La mejor capacidad inmunológica, dada la comunicación neuroinmunoendocrina, es un excelente indicador del estado de salud y de la mejor adaptación al reto que supone el ingreso en el hospital, independientemente del motivo de dicha hospitalización.

Item Type:Article
Uncontrolled Keywords:Longevity, odds ratio, survival prediction
Subjects:Medical sciences > Medicine > Geriatrics
Medical sciences > Biology > Genetics
Medical sciences > Biology > Microbiology
ID Code:61005
Deposited On:18 Jun 2020 11:36
Last Modified:18 Jun 2020 11:36

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