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Effects of moderate static magnetic field on neural systems is a non-invasive mechanical stimulation of the brain possible theoretically?

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Hernando Grande, Antonio and García, Miguel A. and Soto León, Vanesa and Alonso Bonilla, Carlos and Aguilar, Juan and Oliviero, Antonio (2020) Effects of moderate static magnetic field on neural systems is a non-invasive mechanical stimulation of the brain possible theoretically? Frontiers in neuroscience, 14 . ISSN 1662-453X

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Official URL: http://dx.doi.org/10.3389/fnins.2020.00419


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Abstract

Static magnetic fields have been shown to induce effects on the human brain. Different experiments seem to support the idea that moderate static magnetic field can exert some influence on the gating processes of the membrane channels. In this article we visit the order of magnitude of the energy magnetic terms associated with moderate applied field (between 10 and 200 milliteslas). It is shown that gradients of the Zeeman energy associated with the inhomogeneous applied fields can induce pressures of the order of 10^(-2)Pa. The surface tension generated by the magnetic pressure, on the surface delimiting the brain region subject to relevant field and gradients, is found to range between 10^(-1) and 1 mN.m^(-1). These pressures seem to be strong enough to interfere with the elastic and electrostatic energies involved in the channel activation-inactivation-deactivation mechanisms of biological membranes. It has been described that small mechanical force can activate voltage gated potassium channels. Moreover, stretch-activated ion channels are widely described in different biological tissues. Virtually, all these channels can modify their activity if stressed by a sufficient pressure delivered for enough time. We propose mechanical stimulation - possibly not exclusively - as a candidate mechanism how static magnetic field can produce effects in biological systems. It must be emphasized, that such field gradients were not previously proposed as a possible source of neural activity modification.


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©2020 Frontiers Media
This research was funded by the Department of Economy, Industry and Competitiveness and co-financed by the European Union (FEDER) "A way to make Europe" (SAF2016-80647-R), and by "The Michael J. Fox Foundation" (Grant ID: 9205).

Uncontrolled Keywords:Bilayers; excitability; Anisotropy; Lecithin; Static magnetic field; Zeeman energy; Membrane channels; Non-invasive brain stimulation; Mechanical stimulation
Subjects:Sciences > Physics > Materials
Sciences > Physics > Solid state physics
ID Code:61435
Deposited On:13 Jul 2020 00:18
Last Modified:13 Jul 2020 00:18

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