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A Novel and Divergent Gyrovirus with Unusual Genomic Features Detected in Wild Passerine Birds from a Remote Rainforest in French Guiana

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Truchado, Daniel A. and Díaz-Piqueras, José Manuel and Gómez-Lucía, Esperanza and Doménech, Ana and Milá, Borja and Pérez Tris, Javier and Schmidt-Chanasit, Jonas and Cadar, Daniel and Benítez Rico, Laura (2019) A Novel and Divergent Gyrovirus with Unusual Genomic Features Detected in Wild Passerine Birds from a Remote Rainforest in French Guiana. Viruses, 11 (12). p. 1148. ISSN 1999-4915

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Official URL: https://doi.org/10.3390/v11121148



Abstract

Sequence-independent amplification techniques have become important tools for virus discovery, metagenomics, and exploration of viral diversity at the global scale, especially in remote areas. Here, we describe the detection and genetic characterization of a novel gyrovirus, named GyV11, present in cloacal, oral, and blood samples from neotropical wild birds in French Guiana. The molecular epidemiology revealed the presence of GyV11 only in passerine birds from three different species at a low prevalence (0.73%). This is the first characterization and prevalence study of a gyrovirus carried out in resident wild bird populations in a remote region, and provides evidence of the fecal–oral route transmission and local circulation of the virus. The molecular phylogeny of gyroviruses reveals the existence of two distinct gyrovirus lineages in which GyV11 is phylogenetically distinct from previously reported gyroviruses. Furthermore, GyV11 is placed basal in the gyrovirus phylogeny, likely owing to its ancestral origin and marked divergence. This study also provides important insights into the ecology, epidemiology, and genomic features of gyroviruses in a remote neotropical rainforest. The pathogenesis of this virus in avian species or whether GyV11 can infect humans and/or chickens needs to be further investigated.

Resumen (otros idiomas)

En esta publicación se describe la detección mediante análisis metagenómico y la caracterización genómica de un nuevo gyrovirus (GyV11) en muestras cloacales, orales y de sangre de tres especies de paseriformes neotropicales muestreados en la Reserva Natural de Nouragues (Guayana Francesa). La prevalencia del nuevo gyrovirus es baja en la población estudiada (0,73%, n = 406 individuos). GyV11 es filogenéticamente distinto a los gyrovirus reportados previamente, situándose de forma basal en la filogenia de este grupo de virus posiblemente debido a su origen ancestral y marcada divergencia. Este estudio es el primero en caracterizar y analizar la prevalencia de un nuevo gyrovirus en una población de aves silvestres residentes de un área remota y muestra evidencias tanto de la transmisión fecal-oral del virus como de su circulación en la población analizada. Además, pone de manifiesto la importancia de la secuenciación profunda como herramienta para el descubrimiento de nuevos virus en zonas remotas.

Item Type:Article
Uncontrolled Keywords:gyrovirus, passerines, French Guiana, metagenomics, tropical rainforest
Subjects:Medical sciences > Biology > Birds
Medical sciences > Biology > Ecology
Medical sciences > Biology > Genetics
ID Code:61670
Deposited On:27 Jul 2020 14:18
Last Modified:08 Sep 2020 10:10

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