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Contact Lenses as Drug Delivery System for Glaucoma: A Review

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Peral Cerdá, Assumpta and Martínez Águila, Alejandro and Pastrana, Cristina and Huete Toral, Fernando and Carpena Torres, Carlos and Carracedo Rodríguez, Juan Gonzalo (2020) Contact Lenses as Drug Delivery System for Glaucoma: A Review. Applied sciences, 10 (15). p. 5151. ISSN 2076-3417

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Official URL: https://doi.org/10.3390/app10155151




Abstract

Glaucoma is an optical neuropathy associated to a progressive degeneration of retinal ganglion cells with visual field loss and is the main cause of irreversible blindness in the world. The treatment has the aim to reduce intraocular pressure. The first therapy option is to instill drugs on the ocular surface. The main limitation of this is the reduced time of the drug staying on the cornea. This means that high doses are required to ensure its therapeutic effect. A drug-loaded contact lens can diffuse into the post lens tear film in a constant and prolonged flow, resulting in an increased retention of the drug on the surface of the cornea for up to 30 min and thus providing a higher drug bioavailability, increasing the therapeutic efficacy, reducing the amount of administered drug, and thereby provoking fewer adverse events. Several different systems of drug delivery have been studied in recent decades; ranging from more simple methods of impregnating the lenses, such as soaking, to more complex ones, such as molecular imprinting have been proposed. Moreover, different drugs, from those already commercially available to new substances such as melatonin have been studied to improve the glaucoma treatment efficacy. This review describes the role of contact lenses as an innovative drug delivery system to treat glaucoma.


Item Type:Article
Additional Information:

Received: 30 June 2020; Accepted: 21 July 2020; Published: 27 July 2020

Uncontrolled Keywords:Glaucoma, Contact lenses; Drug delivery
Subjects:Medical sciences > Medicine > Pharmacology
Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Contact lenses
ID Code:61973
Deposited On:11 Sep 2020 17:06
Last Modified:14 Sep 2020 08:01

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