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Multimodal determinants of phase-locked dynamics across deep-superficial hippocampal sublayers during theta oscillations

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Navas-Olive, Andrea and Valero, Manuel and Jurado-Parras, Teresa and Salas-Quiroga, Adán de and Averkin, Robert G. and Gambino, Giuditta and Cid, Elena and Liset, M. de la Prida (2020) Multimodal determinants of phase-locked dynamics across deep-superficial hippocampal sublayers during theta oscillations. Nature communications, 11 (2217). pp. 1-14. ISSN ESSN 2041-1723

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Official URL: https://www.nature.com/articles/s41467-020-15840-6



Abstract

Theta oscillations play a major role in temporarily defining the hippocampal rate code by translating behavioral sequences into neuronal representations. However, mechanisms constraining phase timing and cell-type-specific phase preference are unknown. Here, we employ computational models tuned with evolutionary algorithms to evaluate phase preference of individual CA1 pyramidal cells recorded in mice and rats not engaged in any particular memory task. We applied unbiased and hypothesis-free approaches to identify effects of intrinsic and synaptic factors, as well as cell morphology, in determining phase preference. We found that perisomatic inhibition delivered by complementary populations of basket cells interacts with input pathways to shape phase-locked specificity of deep and superficial pyramidal cells. Somatodendritic integration of fluctuating glutamatergic inputs defined cycle-by-cycle by unsupervised methods demonstrated that firing selection is tuneable across sublayers. Our data identify different mechanisms of phase-locking selectivity that are instrumental for flexible dynamical representations of theta sequences.


Item Type:Article
Uncontrolled Keywords:Hippocampus; Biophysical models; Neural circuits
Subjects:Medical sciences > Biology > Molecular biology
Medical sciences > Biology > Neurosciences
ID Code:62158
Deposited On:16 Sep 2020 09:05
Last Modified:16 Sep 2020 09:05

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