Publication: Nueva generación de medicamentos mediante impresión 3D
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2018-02
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Abstract
Las aplicaciones de la impresión 3D se han desarrollado notablemente en los últimos años. Desde su aparición en los años ochenta, surgieron nuevas técnicas de impresión 3D para satisfacer el interés creciente demostrado por diferentes industrias, incluida la industria farmacéutica. La técnica de impresión 3D podría ser revolucionaria en el proceso de fabricación de medicamentos. La facilidad y flexibilidad que presenta, puede resolver algunas limitaciones que demuestra la fabricación tradicional en cuanto a productos farmacéuticos con un proceso de formulación complejo, tales como productos con perfiles de liberación modificada. Al basarse sobre un proceso de fabricación por capas siguiendo las instrucciones minuciosas de un modelo diseñado digitalmente, la diversidad de los productos obtenidos es impresionante. Las posibilidades que parece ofrecer esta nueva tecnología al proceso de fabricación de medicamentos no tienen fin. Esta revisión trata fundamentalmente los sistemas de administración de medicamentos de liberación controlada obtenidos mediante impresión 3D. Se aborda las posibilidades de personalización de tratamiento y fabricación a demanda que ofrece esta tecnología.
The wide spread applications of 3D manufacturing has grown substantially in last few years. Since its appearance in the eighties, many 3D printing techniques have developed in order to satisfy the growing interest demonstrated by many industries including the pharmaceutical industry. The 3D printing technique could prove to be revolutionary in the drug manufacturing process. The ease and flexibility presented, may resolve some limitations that traditional manufacturing shows with pharmaceutical products which require a complex formulation process, such as drugs with modified release profiles. Given that the basic principle, on which this technique relies on, is a layer by layer manufacturing process following instructions of a digitally designed model, the diversity of the products obtained is tremendous. Whether it’s a drug with a specific shape or a combination of drugs designed in particular to meet a patient’s needs, the possibilities that this technique appears to offer for the drug manufacturing process can be described as endless. Although this review, is widely focused in the field of controlled-release drug delivery systems, personalized treatment and on-demand drug manufacturing are also discussed.
The wide spread applications of 3D manufacturing has grown substantially in last few years. Since its appearance in the eighties, many 3D printing techniques have developed in order to satisfy the growing interest demonstrated by many industries including the pharmaceutical industry. The 3D printing technique could prove to be revolutionary in the drug manufacturing process. The ease and flexibility presented, may resolve some limitations that traditional manufacturing shows with pharmaceutical products which require a complex formulation process, such as drugs with modified release profiles. Given that the basic principle, on which this technique relies on, is a layer by layer manufacturing process following instructions of a digitally designed model, the diversity of the products obtained is tremendous. Whether it’s a drug with a specific shape or a combination of drugs designed in particular to meet a patient’s needs, the possibilities that this technique appears to offer for the drug manufacturing process can be described as endless. Although this review, is widely focused in the field of controlled-release drug delivery systems, personalized treatment and on-demand drug manufacturing are also discussed.