Publication: Desarrollo galénico de nuevas formulaciones de indometacina
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2020-11-11
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Universidad Complutense de Madrid
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Abstract
La indometacina (IND) es un agente antiinflamatorio no esteroideo con actividad antiinflamatoria, analgésica y antipirética. Se cree que su efecto farmacológico está mediado a través de la inhibición de la enzima ciclooxigenasa (COX), que es responsable de catalizar el paso limitante de la velocidad en la síntesis de prostaglandinas. Sin embargo, la IND es relativamente versátil, y estudios posteriores han señalado su uso potencial enla terapia de prevención del cáncer. Algunos estudios han observado actividad de la IND en cánceres de piel de melanoma (MSC) y no melanoma (NMSC) en estudios con animales e in vitro...
Indomethacin (IND) is a non-steroidal anti-inflammatory agent with antiinflammatory, analgesic and antipyretic activity. It is believed that its pharmacological effect is mediated through the inhibition of the enzyme cyclooxygenase (COX), which is responsible for catalyzing the rate-limiting step in prostaglandin synthesis. However, IND is relatively versatile, and further studies have pointed to a potential use in cancer prevention therapy. Some studies have reported activity on melanoma (MSC) and non-melanoma (NMSC)skin cancers in animal and in vitro studies...
Indomethacin (IND) is a non-steroidal anti-inflammatory agent with antiinflammatory, analgesic and antipyretic activity. It is believed that its pharmacological effect is mediated through the inhibition of the enzyme cyclooxygenase (COX), which is responsible for catalyzing the rate-limiting step in prostaglandin synthesis. However, IND is relatively versatile, and further studies have pointed to a potential use in cancer prevention therapy. Some studies have reported activity on melanoma (MSC) and non-melanoma (NMSC)skin cancers in animal and in vitro studies...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Farmacia Galénica y Tecnología Alimentaria, leída el 12-01-2020