Publication: Papel de MINDIN en la progresión tumoral y formación del nicho pre-metastásico óseo en el cáncer de próstata
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2021-07-07
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Universidad Complutense de Madrid
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Abstract
El cáncer de próstata es una de la principales patologías que afectan a la población masculina. Sin embargo, se desconocen cuáles son los factores determinantes en su desarrollo. Actualmente, el desafío en el cáncer de próstata es la identificación de marcadores tumorales específicos, fundamental para pronosticar y monitorizar los tumores de próstata con el objetivo de reducir la mortalidad y mantener una calidad de vida aceptable. El hueso es un tejido dinámico que se remodela continuamente ante una gran variedad de estímulos. Además, es un órgano frecuentemente infiltrado por la diseminación metastásica de tumores sólidos, como el de próstata. Esta preferencia, denominada organotropismo, puede deberse a la adquisición de características osteomiméticas por parte de las células tumorales. El osteomimetismo implica que las células tumorales expresan de manera ectópica genes restringidos al tejido óseo y que las predisponen a colonizarlo...
Prostate cancer is one of the main pathologies that affect the male population. However, the determining factors in its development are unknown. Currently, the challenge in prostate cancer is the identification of specific tumor markers, essential to predict and monitor prostate tumors with the aim of reducing mortality and maintaining an acceptable quality of life.Bone is a dynamic tissue that continually remodels in response of a wide variety of stimuli. In addition, it is an organ frequently infiltrated by the metastatic spread of solid tumors, such as prostate cancer. This preference, called organotropism, may be due to the acquisition of osteomimetic characteristics by tumor cells. Osteomimicry implies that tumor cells ectopically express genes restricted to bone tissue and predispose them to colonize it...
Prostate cancer is one of the main pathologies that affect the male population. However, the determining factors in its development are unknown. Currently, the challenge in prostate cancer is the identification of specific tumor markers, essential to predict and monitor prostate tumors with the aim of reducing mortality and maintaining an acceptable quality of life.Bone is a dynamic tissue that continually remodels in response of a wide variety of stimuli. In addition, it is an organ frequently infiltrated by the metastatic spread of solid tumors, such as prostate cancer. This preference, called organotropism, may be due to the acquisition of osteomimetic characteristics by tumor cells. Osteomimicry implies that tumor cells ectopically express genes restricted to bone tissue and predispose them to colonize it...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Bioquímica y Biología Molecular, leída el 01/02/2021