Publication: Estudio de los efectos neuroprotectores de la Noradrenalina mediante las Quimioquinas CCL2 y CX3CL1
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2021-07-22
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Universidad Complutense de Madrid
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Abstract
La progresión de diferentes enfermedades neurodegenerativas, como la enfermedad de Alzheimer (EA) y la enfermedad de Parkinson (EP), se asocia con la disminución de los niveles cerebrales de noradrenalina (NA) debido a la pérdida de neuronas noradrenérgicas del locus coeruleus (LC), la principal fuente de NA en el cerebro (Bondareff et al., 1987) . La EA es la enfermedad neurodegenerativa humana más frecuente, ya que afecta a alrededor de 50millones de personas en todo el mundo. Con el aumento de la esperanza de vida, la incidencia de enfermedades neurodegenerativas también ha aumentado. La EA es una enfermedad multifactorial, lo que significa que existe una interacción compleja entre factores genéticos, ambientales y de envejecimiento. Se han propuesto diferentes mecanismos para explicar la fisiopatología de esta enfermedad y su manifestación clínica más evidente, el trastorno cognitivo o la demencia: la toxicidad del péptido β amiloide (Aβ), la hiperfosforilación de la proteína Tau, el daño oxidativo, la disfunción sináptica, la disfunción colinérgica y la neuroinflamación...
The progression of neurodegenerative diseases is associated with cellular and biochemical dysfunctions that cause neuronal loss. Among these diseases, Alzheimer's disease (AD) and Parkinson's disease (PD) are associated with the decline of noradrenaline's (NA's) brain levels. This reduction is due to the loss of locus coeruleus (LC) noradrenergic neurons, which is the main source of NA in the brain (Bondareff et al., 1987). AD is the most frequent human neurodegenerative disease, as it affects around 50 million people worldwide. With the increase in life expectancy, the incidence of neurodegenerative diseases has also risen. AD is a multifactorial disease, meaning that there is a complex interaction between genetic, environmental, and aging factors. Therefore, there are different mechanisms proposed to explain AD cognitive disorder: Amyloid-β (Aβ) peptide toxicity, Tau disorders, oxidative damage, synaptic dysfunction, cholinergic dysfunction, and neuroinflammation...
The progression of neurodegenerative diseases is associated with cellular and biochemical dysfunctions that cause neuronal loss. Among these diseases, Alzheimer's disease (AD) and Parkinson's disease (PD) are associated with the decline of noradrenaline's (NA's) brain levels. This reduction is due to the loss of locus coeruleus (LC) noradrenergic neurons, which is the main source of NA in the brain (Bondareff et al., 1987). AD is the most frequent human neurodegenerative disease, as it affects around 50 million people worldwide. With the increase in life expectancy, the incidence of neurodegenerative diseases has also risen. AD is a multifactorial disease, meaning that there is a complex interaction between genetic, environmental, and aging factors. Therefore, there are different mechanisms proposed to explain AD cognitive disorder: Amyloid-β (Aβ) peptide toxicity, Tau disorders, oxidative damage, synaptic dysfunction, cholinergic dysfunction, and neuroinflammation...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 22/01/2021