Publication: Papel de la pseudoquinasa Tribbles 3 en cáncer de mama: estudios mecanísticos e implicaciones en el pronóstico del subtipo lumina
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2021-07-30
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Universidad Complutense de Madrid
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Abstract
El cáncer de mama es el tipo tumoral más frecuente en mujeres. Numerosos estudios sobre los procesos moleculares implicados en el desarrollo tumoral mamario han incrementado el conocimiento de esta patología y han permitido la identificación de biomarcadores pronósticos y el desarrollo de nuevas terapias. Sin embargo, sigue siendo la principal causa de muerte por cáncer en mujeres en la mayoría de los países. Se trata de una patología muy heterogénea que se clasifica atendiendo a distintos marcadores moleculares, siendo el subtipo tumoral más frecuente el cáncer de mama luminal, caracterizado por la expresión del receptor de estrógenos y diversas citoqueratinas características de las células epiteliales luminales que conforman los ductos mamarios. TRIB3 es una pseudoquinasa que pertenece a la familia de las proteínas Tribbles y cuya desregulación se ha visto implicada en el desarrollo de distintas patologías, entre las que destacan los trastornos cardiovasculares y el cáncer. Concretamente en cáncer, se ha propuesto que TRIB3 puede desempeñar una acción pro- o antitumoral según el contexto celular y tipo de tumor y, particularmente en cáncer de mama, la bibliografía existente es escasa y poco concluyente...
Breast cancer (BC) is the most common type of cancer in women. Numerous studies have characterized the molecular processes involved in breast cancer development and have allowed the identification of prognostic biomarkers that have led to the implementation of new more selective therapies. Despite these advances, BC remains as the leading cause of death associated with cancer in women in most countries. BC is a very heterogeneous pathology that is classified according to different molecular markers, being the most frequent tumor subtype luminal breast cancer, characterized by the expression of the estrogen receptor and various cytokeratins characteristic of the luminal epithelial cells that constitute the mammary ducts. TRIB3 is a pseudokinase that belongs to the family of Tribbles proteins and whose dysregulation has been implicated in the development of different pathologies, including cardiovascular disorders and cancer. Specifically in cancer, it has been proposed that TRIB3 can play a pro- or antitumor role depending on the cellular context. Specifically in breast cancer, the existing literature is scarce and inconclusive...
Breast cancer (BC) is the most common type of cancer in women. Numerous studies have characterized the molecular processes involved in breast cancer development and have allowed the identification of prognostic biomarkers that have led to the implementation of new more selective therapies. Despite these advances, BC remains as the leading cause of death associated with cancer in women in most countries. BC is a very heterogeneous pathology that is classified according to different molecular markers, being the most frequent tumor subtype luminal breast cancer, characterized by the expression of the estrogen receptor and various cytokeratins characteristic of the luminal epithelial cells that constitute the mammary ducts. TRIB3 is a pseudokinase that belongs to the family of Tribbles proteins and whose dysregulation has been implicated in the development of different pathologies, including cardiovascular disorders and cancer. Specifically in cancer, it has been proposed that TRIB3 can play a pro- or antitumor role depending on the cellular context. Specifically in breast cancer, the existing literature is scarce and inconclusive...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Químicas, leída el 02/07/2021