Publication: Control de la leishmaniosis canina: evaluación de nuevas alternativas profilácticas y terapéuticas
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2021-08-05
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Universidad Complutense de Madrid
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Abstract
La leishmaniosis visceral canina, es una importante enfermedad parasitaria zoonótica. Los perros infectados por Leishmania infantum son los principales reservorios urbanos de esta patología y juegan un papel importante en la transmisión de la enfermedad a los humanos. En los últimos años, se han realizados numerosos avances en los conocimientos de la biología, epidemiología, patología, diagnóstico, tratamiento, prevención y control de esta enfermedad; sin embargo, hasta la fecha no se ha conseguido una cura y una profilaxis eficaz en el perro. Dado el interés que despierta la leishmaniosis canina en los veterinarios clínicos, propietarios y criadores de perros, junto a la importancia sanitaria añadida debido a su carácter zoonótico en áreas endémicas, hemos creído conveniente la realización de este estudio con la finalidad de evaluar nuevas aproximaciones en el campo del control de la leishmaniosis canina mediante el estudio y seguimiento de la capacidad infectiva, inmunogénica y protectora de la infección experimental de perros Beagle, con cepas no virulentas de Leishmania infantum aisladas de pacientes coinfectados con VIH y la evaluación de la seguridad, el comportamiento farmacocinético y la eficacia terapéutica de una nueva formulación inosomada asociando el estibogluconato sódico y la paromomicina en el tratamiento de perros sintomáticos infectados experimentalmente con L. infantum, mediante tres ensayos clínicos...
Canine visceral leishmaniosis is an important zoonotic parasitic disease, with dogs infected with Leishmania infantum the main urban reservoirs of this pathology and they play an important role in the transmission of disease to humans. In recent years, numerous advances have been made in the knowledge of biology, epidemiology, pathology, diagnosis, treatment, prevention and control of this disease; however, to date, no cure and prophylaxis has been achieved in one hundred percent of cases in the urban host of visceral leishmaniosis that is the dog. Given the interest of canine leishmaniosis in clinical veterinarians, owners and breeders of dogs, together with the added health importance due to its zoonotic character in endemic areas, we have felt it appropriate to conduct this study in order to evaluate new approaches in the field of canine leishmaniosis control by studying and monitoring the infectious, immunogenic and protective capacity of experimental infection of Beagle dogs, with non-virulent strains of Leishmania infantum isolated from patients co-infected with HIV and evaluating the safety, pharmacokinetic behavior and therapeutic efficacy of a new inosomated formulation associating sodium stibogluconate and paromomycin in the treatment of symptomatic dogs experimentally infected with L. infantum, through three clinical trials...
Canine visceral leishmaniosis is an important zoonotic parasitic disease, with dogs infected with Leishmania infantum the main urban reservoirs of this pathology and they play an important role in the transmission of disease to humans. In recent years, numerous advances have been made in the knowledge of biology, epidemiology, pathology, diagnosis, treatment, prevention and control of this disease; however, to date, no cure and prophylaxis has been achieved in one hundred percent of cases in the urban host of visceral leishmaniosis that is the dog. Given the interest of canine leishmaniosis in clinical veterinarians, owners and breeders of dogs, together with the added health importance due to its zoonotic character in endemic areas, we have felt it appropriate to conduct this study in order to evaluate new approaches in the field of canine leishmaniosis control by studying and monitoring the infectious, immunogenic and protective capacity of experimental infection of Beagle dogs, with non-virulent strains of Leishmania infantum isolated from patients co-infected with HIV and evaluating the safety, pharmacokinetic behavior and therapeutic efficacy of a new inosomated formulation associating sodium stibogluconate and paromomycin in the treatment of symptomatic dogs experimentally infected with L. infantum, through three clinical trials...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Veterinaria, Departamento de Farmacología y Toxicología, leída el 01-02-2021