Publication: Identificación de un perfil molecular predictor de albuminuria en pacientes hipertensos con supresión crónica del sistema renina-angiotensina
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2022-03-16
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Universidad Complutense de Madrid
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Abstract
La albuminuria moderadamente elevada o microalbuminuria es una condición patológica definida como la presencia anormalmente alta de albúmina en la orina por encima de 30 mg/g de cociente albúmina/creatinina (ACR). Es considerada un indicador de riesgo de morbimortalidad cardiovascular y de daño renal. Sin embargo, cuando se detecta en la orina ya se ha producido lesión en el órgano. Numerosas evidencias clínicas apuntan que existe una asociación continua entre la albuminuria y el riesgo cardio-renal incluso por debajo de los rangos de microalbuminuria establecidos. Sin embargo, los sujetos normoalbuminúricos generalmente se consideran sin riesgo en la práctica clínica, aun cuando un porcentaje no despreciable de ellos desarrollan microalbuminuria a medio-largo plazo. Por ello, si la determinación de riesgo cardio-renal solo se basa en un ACR >30 mg/g, un porcentaje significativo de la población puede estar quedando fuera del alcance de un manejo terapéutico temprano que evite la progresión a una condición patológica...
Moderately elevated albuminuria or microalbuminuria is a pathological condition defined as the abnormally high presence of albumin in urine; above 30 mg/g albumin/creatinine ratio (ACR). It is considered a marker of cardiovascular risk and renal damage. However, by the time it is detected in the urine, organ damage has already occurred. Clinical evidence reveals that a continuous association between albuminuria and cardio-renal risk exists even below established microalbuminuria ranges. However, normoalbuminuric subjects are considered at no risk in clinical practice even though a non-negligible percentage of them develops microalbuminuria in the medium to long term. If cardio-renal risk determination is only based on ACR >30 mg/g, a significant percentage of the population may be falling outside the scope of early therapeutic management that would avoid progression to a pathological condition...
Moderately elevated albuminuria or microalbuminuria is a pathological condition defined as the abnormally high presence of albumin in urine; above 30 mg/g albumin/creatinine ratio (ACR). It is considered a marker of cardiovascular risk and renal damage. However, by the time it is detected in the urine, organ damage has already occurred. Clinical evidence reveals that a continuous association between albuminuria and cardio-renal risk exists even below established microalbuminuria ranges. However, normoalbuminuric subjects are considered at no risk in clinical practice even though a non-negligible percentage of them develops microalbuminuria in the medium to long term. If cardio-renal risk determination is only based on ACR >30 mg/g, a significant percentage of the population may be falling outside the scope of early therapeutic management that would avoid progression to a pathological condition...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Químicas, Departamento de Bioquímica y Biología Molecular, leída el 27-01-2022