Publication: Histocompatibilidad [HLA] KIR, A, B, C, DR y DQ en el fallo reproductivo recurrente
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2022-04-04
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Universidad Complutense de Madrid
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Abstract
El fallo reproductivo recurrente (FRR) incluye dos entidades: aborto espontáneo recurrente (AR) y fallo de implantación recurrente (FIR). La incidencia de AR en la población general es de hasta el 1-3% y la de FIR en las mujeres que se han sometido a una FIV es de entre 10-15%.Para que una gestación llegue a término precisa de una adecuada tolerancia por parte del sistema inmunológico materno frente al embrión. Entre las muchas etiologías conocidas, el reconocimiento del HLA del embrión en el entorno materno se reconoce como un factor relevante de FRR...
Recurrent reproductive failure [RRF] includes two factors: recurrent spontaneous abortion [RSA] and recurrent implantation failure [RIF]. The rate of RSA in the general population is up to 1-3% and that of RIF in women who have undergone IVF is between 10-15%.To achieve a term pregnancy, there must be a certain tolerance of the embryo by the maternal immune system. Among the many etiologies known, embryo HLA recognition in the maternal environment is known as a relevant factor in RRF..
Recurrent reproductive failure [RRF] includes two factors: recurrent spontaneous abortion [RSA] and recurrent implantation failure [RIF]. The rate of RSA in the general population is up to 1-3% and that of RIF in women who have undergone IVF is between 10-15%.To achieve a term pregnancy, there must be a certain tolerance of the embryo by the maternal immune system. Among the many etiologies known, embryo HLA recognition in the maternal environment is known as a relevant factor in RRF..
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Investigación Biomédica, leída el 05-11-2021