Publication: Respuestas de las células ganglionares de la retina a la lesión y su prevención
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2022-04-19
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Universidad Complutense de Madrid
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Abstract
Las células ganglionares de la retina (CGR) son las únicas células de la retina que envían la información de la retina al cerebro y por ello son indispensables para la visión. Se trata de una población heterogénea ya que se ha documentado que comprende hasta 46 tipos celulares diferentes en el ratón. Los diferentes tipos de CGR codifican un aspecto particular de la información visual y la transmiten al cerebro para realizar funciones formadoras de imagen (FI) o no formadoras de imagen (NFI). Un tipo de CGR contiene el pigmento visual melanopsina, lo que le permite realizar fototransducción y por ello se denomina CGR intrínsecamente fotosensible (CGRif).Se han descrito hasta 6 tipos de CGRif en el ratón que realizan las funciones NFI de nuestro sistema visual. Los diferentes tipos de CGR responden de un modo diferente a diferentes tipos de lesión y también a la neuroprotección...
The Retinal Ganglion Cells (RGCs) are the only retinal cells that send information to the brain and thus are essential for vision. It is a heterogeneous population since up to 46 different RGC types have been documented in mice. The different RGC types encode a particular aspect of visual information and send it to the brain, where theycontribute to image forming (IF) and non-image forming (NIF) visual functions. A type of RGC contains the visual pigment melanopsin and performs phototransductionand thus has been named intrinsically photosensitive RGC (ipRGC). Six types of ipRGCs have been described in mice that perform the NIF functions of the visual system. Recent studies have documented that the different RGC types respond differently to different types of injury and to neuroprotection...
The Retinal Ganglion Cells (RGCs) are the only retinal cells that send information to the brain and thus are essential for vision. It is a heterogeneous population since up to 46 different RGC types have been documented in mice. The different RGC types encode a particular aspect of visual information and send it to the brain, where theycontribute to image forming (IF) and non-image forming (NIF) visual functions. A type of RGC contains the visual pigment melanopsin and performs phototransductionand thus has been named intrinsically photosensitive RGC (ipRGC). Six types of ipRGCs have been described in mice that perform the NIF functions of the visual system. Recent studies have documented that the different RGC types respond differently to different types of injury and to neuroprotection...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Inmunología, Oftalmología y Otorrinolaringología, leída el 20-12-2021