Publication: Influencia de variantes genéticas en la respuesta ponderal a la cirugía bariátrica
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2022-04-28
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Universidad Complutense de Madrid
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Abstract
La cirugía bariátrica (CB) consigue efectos sustanciales y persistentes en la pérdida de peso en pacientes con obesidad mórbida (OM) y mejora el tratamiento de las comorbilidades asociadas a la obesidad. Existe una variabilidad interindividual en la respuesta ponderal tras CB, a corto plazo entre el 15 y el 35 % de los pacientes no alcanza su objetivo de pérdida de peso y a largo plazo entre el 10-80 % de los pacientes recuperan una parte significativa del peso perdido. En la fisiopatología de la obesidad y en la respuesta a la CB intervienen complejas interacciones entre factores biológicos y hormonales, ambientales, conductuales y genéticos que regulan el peso corporal. Los estudios de asociación genómica han identificado más de 300 polimorfismos implicados en el comportamiento alimentario y el gasto energético, asociados con Indice de Masa Corporal (IMC) y rasgos de adiposidad, pero en la intervención con CB los estudios son muy limitados. El objetivo primario de nuestro trabajo es identificar marcadores genéticos asociados con OM y marcadores genéticos asociados con la pérdida de peso y su mantenimiento a largo plazo, tras diferentes técnicas quirúrgicas de CB. Las variantes genéticas analizadas codifican para péptidos gastrointestinales, sus receptores o proteínas que intervienen en su expresión, implicadas en el control del apetito y metabolismo...
Bariatric surgery (BS) achieves substantial and persistent effects on weight loss in patients with morbid obesity (MO) and improves the management of obesity-associated comorbidities. Thereis inter-individual variability in weight response after BS, with estimates of aproximately 15-35% of patients failing to achieve their weight loss goal in the short term and 10-80 % of patients regaining a significant portion of their weight loss in the long term. The pathophysiology of obesity and the response to BS involve complex interactions between biological and hormonal, environmental, behavioural and genetic factors that regulate body weight. Genome-wide association studies have identified more than 300 polymorphisms involved in eating behaviour and energy expenditure, associated with Body Mass Index (BMI) and adiposity traits, however,in BS intervention, studies are very limited. The primary objective of our work is to identify genetic markers associated with MO and genetic markers associated with weight loss and its long-term maintenance after different BS surgical techniques. The genetic variants analysed encode for gastrointestinal peptides, their receptors or proteins involved in their expression, involved in appetite control and metabolism...
Bariatric surgery (BS) achieves substantial and persistent effects on weight loss in patients with morbid obesity (MO) and improves the management of obesity-associated comorbidities. Thereis inter-individual variability in weight response after BS, with estimates of aproximately 15-35% of patients failing to achieve their weight loss goal in the short term and 10-80 % of patients regaining a significant portion of their weight loss in the long term. The pathophysiology of obesity and the response to BS involve complex interactions between biological and hormonal, environmental, behavioural and genetic factors that regulate body weight. Genome-wide association studies have identified more than 300 polymorphisms involved in eating behaviour and energy expenditure, associated with Body Mass Index (BMI) and adiposity traits, however,in BS intervention, studies are very limited. The primary objective of our work is to identify genetic markers associated with MO and genetic markers associated with weight loss and its long-term maintenance after different BS surgical techniques. The genetic variants analysed encode for gastrointestinal peptides, their receptors or proteins involved in their expression, involved in appetite control and metabolism...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, leída el 22-02-2022